Benzenecarboximidoyl chloride, N-hydroxy-4-(1-methylethyl)-

Base Information

• Chemical Name: Benzenecarboximidoyl chloride, N-hydroxy-4-(1-methylethyl)-
• CAS No.: 61946-90-5
• Molecular Formula: C10H12ClNO
• Molecular Weight: 197.664
• Mol file: 61946-90-5.mol

Synonyms:

Chemical Property of Benzenecarboximidoyl chloride, N-hydroxy-4-(1-methylethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenecarboximidoyl chloride, N-hydroxy-4-(1-methylethyl)-

There total 3 articles about Benzenecarboximidoyl chloride, N-hydroxy-4-(1-methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-isopropylbenzaldehyde oxime (3717-17-7,3717-18-8,13372-80-0) → 4-isopropylphenylhydroximoyl chloride (61946-90-5)

Guidance literature:

With chlorine; In hydrogenchloride; at 2 - 5 ℃;

DOI:10.1023/A:1012453012799

Reference yield:

(E)-4-isopropylbenzaldehyde oxime (3717-17-7) → 4-isopropylphenylhydroximoyl chloride (61946-90-5)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 - 40 ℃; for 1h;

DOI:10.1016/j.tetlet.2016.11.023

Reference yield:

(4-isopropylbenzaldehyde) (122-03-2) → 4-isopropylphenylhydroximoyl chloride (61946-90-5)

Guidance literature:

Multi-step reaction with 2 steps

1: hydroxylamine

2: N-chloro-succinimide / N,N-dimethyl-formamide

With N-chloro-succinimide; hydroxylamine; In N,N-dimethyl-formamide;

DOI:10.1007/s00706-010-0265-9

upstream raw materials:

4-isopropylbenzaldehyde oxime

(4-isopropylbenzaldehyde)

(E)-4-isopropylbenzaldehyde oxime

Downstream raw materials:

N-Hydroxy-4-isopropyl-thiobenzimidic acid 2-diethylamino-ethyl ester; hydrochloride

(5R,6R,10S)-10-(4-chlorophenyl)-14-[(E)-1-(4-chlorophenyl)methylidene]-3,9-di(4-isopropylphenyl)-12-(1-phenylethyl)-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]tetradeca-2,8-diene

(5S,6S,10R)-10-(4-chlorophenyl)-14-[(E)-1-(4-chlorophenyl)methylidene]-3,9-di(4-isopropylphenyl)-12-(1-phenylethyl)-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]tetradeca-2,8-diene

(5R,6R,10S)-10-(2,4-dichlorophenyl)-14-[(E)-1-(2,4-dichlorophenyl)methylidene]-3,9-di(4-isopropylphenyl)-12-(1-phenylethyl)-1,4,7-trioxa-2,8,12-triazadispiro[4.0.4.4]tetradeca-2,8-diene

Refernces

• 1、 Khalifeh, Reza,Shahriarpour, Fatemeh,Sharghi, Hashem,Aberi, Mahdi. "Copper-catalysed synthesis of 3,5-disubstituted isoxazoles enabled by pyridinyl benzimidazol (PBI) as a bidentate N-chelating ligand under mild conditions". . p. 813 - 821. Retrieved 2018/03/01.
• 2、 Fershtat, Leonid L.,Epishina, Margarita A.,Ovchinnikov, Igor V.,Struchkova, Marina I.,Romanova, Anna A.,Ananyev, Ivan V.,Makhova, Nina N.. "Side-chain prototropic tautomerism of 4-hydroxyfuroxans in methylation reactions". supporting information. p. 5685 - 5689. Retrieved 2016/11/28.