1-Hydroxy-2,2-dimethyl-5-phenylpyrrolidine

Base Information

Chemical Name:1-Hydroxy-2,2-dimethyl-5-phenylpyrrolidine
CAS No.:62020-90-0
Molecular Formula:C₁₂H₁₇NO
Molecular Weight:191.273
Hs Code.:
DSSTox Substance ID:DTXSID70423727

Synonyms:1-Hydroxy-2,2-dimethyl-5-phenylpyrrolidine;62020-90-0;SCHEMBL441198;DTXSID70423727;GDRSLHOTNAULDH-UHFFFAOYSA-N

Suppliers and Price of 1-Hydroxy-2,2-dimethyl-5-phenylpyrrolidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-Hydroxy-2,2-dimethyl-5-phenylpyrrolidine

Chemical Property:

XLogP3:2.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:191.131014166
Heavy Atom Count:14
Complexity:197

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(CCC(N1O)C2=CC=CC=C2)C

Technology Process of 1-Hydroxy-2,2-dimethyl-5-phenylpyrrolidine

There total 3 articles about 1-Hydroxy-2,2-dimethyl-5-phenylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58134-17-1
2,2-dimethyl-5-phenyl-3,4-dihydro-2H-pyrrole 1-oxide

: 62020-90-0
5-Phenyl-2,2-dimethyl-1-hydroxylpyrrolidine

: 40936-12-7
(2,2-dimethyl-5-phenyl-1-pyrrolidinyl)oxy radical

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether; at 0 - 5 ℃; for 1.5h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;
DOI:10.1002/mrc.1260321203

Reference yield:

: 3317-61-1
5,5-Dimethyl-1-pyrroline N-oxide

: 62020-90-0
5-Phenyl-2,2-dimethyl-1-hydroxylpyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) copper(II) acetate monohydrate, 28percent aq. NH₃, O₂ / 1.) Et₂O, r.t., overnight, 2.) MeOH

2: LiAlH₄ / diethyl ether / 1.5 h / 0 - 5 °C

With ammonium hydroxide; lithium aluminium tetrahydride; oxygen; copper diacetate; In diethyl ether;
DOI:10.1002/mrc.1260321203