58134-17-1

Usage

InChI:InChI=1/C12H15NO/c1-12(2)9-8-11(13(12)14)10-6-4-3-5-7-10/h3-7H,8-9H2,1-2H3

Upstream product

• 3317-61-1 5,5-Dimethyl-1-pyrroline N-oxide 
• 97344-88-2 isopentenylmagnesium bromide 
• 100-52-7 benzaldehyde 
• 143682-84-2 4-methyl-1-phenyl-4-penten-1-ol 
• 1078-36-0 4-methyl-1-phenyl-4-pentene-1-one 
• 1024596-42-6 4-methyl-1-phenylpent-4-en-1-one oxime 

Downstream Products

• 53675-97-1 2,2-dimethyl-5-phenyl-2H-pyrrole 
• 122546-92-3 3-benzoyloxy-5,5-dimethyl-2-phenyl-1-pyrroline 
• 53182-78-8 5,5-dimethyl-3-oxo-2-phenyl-1-pyrroline 1-oxide 
• 58518-84-6 4-methyl-4-nitro-1-phenylpentan-1-one 
• 92050-09-4 4-methyl-4-nitro-1-phenylpentane-1,2-dione 
• 121261-26-5 3-benzyloxy-5,5-dimethyl-3-nitro-2-phenyl-1-pyrroline 
• 62020-90-0 5-Phenyl-2,2-dimethyl-1-hydroxylpyrrolidine 
• 40936-12-7 (2,2-dimethyl-5-phenyl-1-pyrrolidinyl)oxy radical 
• 122546-98-9 5,5-dimethyl-2-phenyl-1-pyrrolin-3-ol 
• 96915-33-2 dimethyl 3a,4,5,6-tetrahydro-6,6-dimethyl-3a-phenylpyrrolo<1,2-b>isoxazole-2,3-dicarboxylate 
• 96915-32-1 hexahydro-6,6-dimethyl-3,3a-diphenylpyrrolo<1,2-b><1,2,4>oxadiazol-2-one 

Relevant academic research and scientific papers

Copper-Catalyzed Cope-Type Hydroamination of Nonactivated Olefins toward Cyclic Nitrones: Scope, Mechanism, and Enantioselective Process Development

The catalytic synthesis of cyclic nitrones, an important type of functional molecules for both synthetic chemistry and related fields, remains underdeveloped. Herein we report the copper-catalyzed Cope-type hydroamination of oximes with pendant nonactivated olefins, which enables facile access to a series of five- and six-membered cyclic nitrones under mild conditions. In this study, heterocycle-tethered oximes were employed in the Cope-type hydroamination reaction for the first time. High enantioselectivity was achieved for carbon-tethered γ,δ-vinyl oximes to afford enantioenriched five-membered cyclic nitrones. The results of preliminary mechanistic studies indicate a mononuclear catalytic species and a unified catalytic pathway over a large temperature range.

New 2-Substituted Pyrroline-N-oxides: An EPR Solvent Study of the Radical Spin Adducts

Ten substituted 5,5-dimethyl-1-pyrroline-N-oxides as well as the parent nitrene spin trap (DMPO) were prepared: 5,5-dimethyl-1-pyrroline-N-oxide, 2,5,5-trimethyl-1-pyrroline-N-oxide, 2-tert-butyl-5,5-dimethyl-1-pyrroline-N-oxide, 2-phenyl-5,5-dimethyl-1-pyrroline-N-oxide, 2-d5-phenyl-5,5-dimethyl-1-pyrroline-N-oxide, 2-phenyl-5,5-dimethyl-1-pyrroline-N-oxide-nitronyl-13C, 2-(4-fluorophenyl)-5,5-dimethyl-1-pyrroline-N-oxide, 2-(4-chlorophenyl)-5,5-dimethyl-1-pyrroline-N-oxide, 2-(4-tert-butylphenyl)-5,5-dimethyl-1-pyrroline-N-oxide, 2-(4-methylphenyl)-5,5-dimethyl-1-pyrroline-N-oxide and 2-(2-methylphenyl)-5,5-dimethyl-1-pyrroline-N-oxide.Analytical (i.e.EPR-grade) samples of these novel cyclic nitrones were obtained and characterized by (among other methods) 1H NMR spectroscopy.Reduction of DMPO and these various 2-substituted cyclic nitrones gave the corresponding cyclic N,N-dialkylhydroxylamines, whose structure and conformations were also analyzed by 1H NMR spectroscopy.Air oxidation of these cyclic N,N-dialkylhydroxylamines provided access to the EPR spectra of the hydrogen, methyl, tert-butyl, phenyl, d5-phenyl, nitronyl-13C-phenyl, 4-fluorophenyl, 4-chlorophenyl, 4-tert-butylphenyl, 4-methylphenyl and 2-methylphenyl cyclic aminoxyl (pyrrolidine N-oxyl nitroxide) radical spin adducts of DMPO.The 14N, 13C (where applicable) and 1H hyperfine splitting constants of these aminoxyl adducts in ten solvents of widely different polarities (e.g., hexane to water) were measured and the solvent effect on these parameters was evaluated.It was found that for the various 2-substituted DMPO-type apin adducts both the nitrogen and β-hydrogen EPR hyperfine splittings correlated linearly (r2 >/= 0.90) with typical solvent polarity parameters such as ET(30).The correlation between the nitrogen and β-hydrogen hyperfine splitting constants were even more linear (r2 >/= 0.97). - Keywords: electron paramagnetic resonance NMR 1H, 14N and 13C hyperfine splittings Spin traps Spin adducts Nitrones (1-pyrroline-N-oxides)