N-[(Benzyloxy)carbonyl]-L-leucyl-L-alaninamide

Base Information

• Chemical Name: N-[(Benzyloxy)carbonyl]-L-leucyl-L-alaninamide
• CAS No.: 62074-75-3
• Molecular Formula: C17H25N3O4
• Molecular Weight: 335.403
• DSSTox Substance ID: DTXSID60561086
• Nikkaji Number: J518.704D
• Wikidata: Q82444746
• Mol file: 62074-75-3.mol

Synonyms:62074-75-3;N-[(Benzyloxy)carbonyl]-L-leucyl-L-alaninamide;DTXSID60561086

Chemical Property of N-[(Benzyloxy)carbonyl]-L-leucyl-L-alaninamide

Chemical Property:

• XLogP3: 1.9
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 9
• Exact Mass: 335.18450629
• Heavy Atom Count: 24
• Complexity: 434

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)CC(C(=O)NC(C)C(=O)N)NC(=O)OCC1=CC=CC=C1
• Isomeric SMILES: C[C@@H](C(=O)N)NC(=O)[C@H](CC(C)C)NC(=O)OCC1=CC=CC=C1

Technology Process of N-[(Benzyloxy)carbonyl]-L-leucyl-L-alaninamide

There total 6 articles about N-[(Benzyloxy)carbonyl]-L-leucyl-L-alaninamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

benzyloxycarbonyl-L-leucine benzyl ester (124980-31-0) + (S)-alaninamide hydrochloride (33208-99-0) → Cbz-Leu-Ala-NH2 (62074-75-3)

Guidance literature:

With Alcalase; In tert-Amyl alcohol; at 5 ℃; for 96h;

DOI:10.1002/jccs.199900046

Reference yield: 72.4%

Cbz-Leu-OCH2CONH2 + L-alanine amide (7324-05-2) → Z-Leu-OH (2018-66-8) + Cbz-Leu-Ala-NH2 (62074-75-3)

Guidance literature:

With phosphate buffer; α-chymotrypsin; In dimethyl sulfoxide; at -24 ℃; for 6h; pH=8.0;

DOI:10.1016/j.tetasy.2005.10.042

Reference yield: 71.0%

L-alanine amide (7324-05-2) + Cbz-D,L-Leu-OBzl (126401-00-1) → Cbz-Leu-Ala-NH2 (62074-75-3)

Guidance literature:

In tert-butyl alcohol; at 35 ℃; for 2h; industrial alkaline protease alcalase;

DOI:10.1021/jo00051a052

upstream raw materials:

L-alanine amide

N-benzyloxycarbonyl-L-leucine methyl ester

Cbz-D,L-Leu-OBzl

benzyloxycarbonyl-L-leucine benzyl ester