N-Benzyloxycarbonyl-L-leucine

Base Information

Chemical Name:N-Benzyloxycarbonyl-L-leucine
CAS No.:2018-66-8
Molecular Formula:C14H19NO4
Molecular Weight:265.309
Hs Code.:29242990
European Community (EC) Number:217-960-3
DSSTox Substance ID:DTXSID80174011
Nikkaji Number:J71.248E
Wikidata:Q27103608
Metabolomics Workbench ID:51656
Mol file:2018-66-8.mol

Synonyms:2018-66-8;Z-Leu-OH;N-Cbz-L-leucine;N-Benzyloxycarbonyl-L-leucine;N-Carbobenzoxy-L-leucine;Carbobenzoxy-L-leucine;N-Carbobenzyloxy-L-leucine;Z-L-Leucine;Carbobenzoxyleucine;Carbobenzyloxy-L-leucine;Benzyloxycarbonyl-L-leucine;Benzyloxycarbonylleucine;N-Benzyloxycarbonylleucine;Cbz-Leucine;Leucine, N-carboxy-, N-benzyl ester, L-;NSC 60039;N-((Phenylmethoxy)carbonyl)-L-leucine;L-N-Carboxyleucine N-benzyl ester;Cbz-L-Leu-OH;cbz-leu-oh;N-(Benzyloxycarbonyl)-L-leucine;EINECS 217-960-3;N-[(phenylmethoxy)carbonyl]-L-leucine;Leucine, N-[(phenylmethoxy)carbonyl]-;BRN 1253861;L-Leucine, N-((phenylmethoxy)carbonyl)-;(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoic acid;N(alpha)-Benzyloxycarbonyl-L-leucine;3-06-00-01503 (Beilstein Handbook Reference);(s)-2-(benzyloxycarbonylamino)-4-methylpentanoic acid;(2S)-2-(Benzyloxycarbonylamino)-4-methylpentanoic acid;(2S)-2-{[(benzyloxy)carbonyl]amino}-4-methylpentanoic acid;cbz-l-leucine;MFCD00026494;L-Leucine, N-[(phenylmethoxy)carbonyl]-;N-(Carbobenzoxy)leucine;n-[(benzyloxy)carbonyl]-l-leucine;L-(Carbobenzyloxy)leucine;(S)-2-(((Benzyloxy)carbonyl)amino)-4-methylpentanoic acid;N-Cbz-leucine;Cbz-Leu;ZLeuOH;(CARBOBENZYLOXY)-L-LEUCINE;Cbz-L-LeuOH;N-(Phenylmethoxy)carbonyl-L-leucine;Z-Leu;n-carbobenzyloxyleucine;CBZ-L-Leu;N-Z-Leu-OH;N-benzyloxycarbonyl-leucin;C04335;N-benzoxycarbonyl-L-leucine;N-(carbobenzoxy)-L-leucine;Z-Leu-OH, 97%;N-ALPHA-CBZ-L-LEUCINE;SCHEMBL222158;N-benzyloxycarbonyl-(S)-leucine;((Benzyloxy)carbonyl)-L-leucine;CHEBI:28282;DTXSID80174011;Nalpha -benzyloxycarbonyl-L-leucine;CS-B1638;HY-Y0555;[(phenylmethoxy)carbonyl]-L-leucine;AKOS015924104;AM81876;FD21888;FS-4054;Nalpha -[(benzyloxy)carbonyl]-L-leucine;AC-17155;LS-87816;Z-Leu-OH, purum, >=96.0% (T);N-{[(phenylmethyl)oxy]carbonyl}-L-leucine;EN300-121296;J-300161;J-505186;N-alpha-BenZyloxycarbonyl-L-leucine (CbZ-L-Leu-OH);Q-101700;Q27103608

Suppliers and Price of N-Benzyloxycarbonyl-L-leucine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
Z-L-leucine
25g
$ 177.00

TRC
N-Cbz-L-leucine
50g
$ 150.00

TCI Chemical
N-Carbobenzoxy-L-leucine >96.0%(T)
5g
$ 12.00

TCI Chemical
N-Carbobenzoxy-L-leucine >96.0%(T)
25g
$ 33.00

Sigma-Aldrich
Z-Leu-OH 97% (HPLC)
25ml
$ 90.20

Medical Isotopes, Inc.
N-Cbz-L-leucine
1 g
$ 610.00

Labseeker
BENZYLOXYCARBONYL-L-LEUCINE 95
5kg
$ 1100.00

Labseeker
BENZYLOXYCARBONYL-L-LEUCINE 95
1kg
$ 500.00

Iris Biotech GmbH
Z-L-Leu-OH
100 g
$ 128.25

Iris Biotech GmbH
Z-L-Leu-OH
25 g
$ 60.75

Total 132 raw suppliers

Chemical Property of N-Benzyloxycarbonyl-L-leucine

Chemical Property:

Appearance/Colour:yellow oil or weak solid
Vapor Pressure:1.28E-08mmHg at 25°C
Refractive Index:n20/D 1.512(lit.)
Boiling Point:442.8 °C at 760 mmHg
PKA:4.00±0.21(Predicted)
Flash Point:221.6 °C
PSA：75.63000
Density:1.158 g/cm³
LogP:2.80300
Storage Temp.:2-8°C
Water Solubility.:Not miscible or difficult to mix in water. Soluble in chloroform, DMSO and methanol.
XLogP3:2.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:7
Exact Mass:265.13140809
Heavy Atom Count:19
Complexity:298

Purity/Quality:

99% ^*data from raw suppliers

Z-L-leucine ^*data from reagent suppliers

Safty Information:

Pictogram(s): Xn
Hazard Codes:Xn
Statements: 10-20/22-37/38-40-41-36/37/38-20/21/22-67-63-19
Safety Statements: 16-26-36/37/39-45-36-36/37-60

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:CC(C)CC(C(=O)O)NC(=O)OCC1=CC=CC=C1
Isomeric SMILES:CC(C)C[C@@H](C(=O)O)NC(=O)OCC1=CC=CC=C1
Uses Reactant for:Peptide-based preparation of potential antitumor agentsPreparation of cyclopropyl peptidomimeticsPeptide synthesis

Technology Process of N-Benzyloxycarbonyl-L-leucine

There total 57 articles about N-Benzyloxycarbonyl-L-leucine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.4%

: Cbz-Leu-OCH₂CONH₂

: 687-51-4,13079-20-4,13366-40-0,15893-47-7
H-L-Leu-NH₂

: 2018-66-8
Z-Leu-OH

: 71800-39-0
N-benzyloxycarbonylated amide of L-leucylleucine

Guidance literature:: With phosphate buffer; α-chymotrypsin; In dimethyl sulfoxide; at -24 ℃; for 4h; pH=8.0;
DOI:10.1016/j.tetasy.2005.10.042

Reference yield: 88.0%

: 3242-70-4
Z-Leu-NHNHPh

: 2018-66-8
Z-Leu-OH

Guidance literature:: With oxygen; In N,N-dimethyl-formamide; for 16h; tyrosinase, phosphate buffer pH 7;
DOI:10.1016/S0040-4039(99)00549-3

Reference yield: 87.0%

: (S)-2-Benzyloxycarbonylamino-4-methyl-pentanoic acid 2-trimethylsilanyl-ethoxymethyl ester

: 2018-66-8
Z-Leu-OH

Guidance literature:: With magnesium bromide; In dichloromethane; for 2h; Ambient temperature; addition at -20 deg C, 0.5 h;
DOI:10.1016/S0040-4039(97)00863-0