1-Benzyl-4-phenylpiperidine-2,6-dione

Base Information

• Chemical Name: 1-Benzyl-4-phenylpiperidine-2,6-dione
• CAS No.: 62143-51-5
• Molecular Formula: C18H17NO2
• Molecular Weight: 279.338
• DSSTox Substance ID: DTXSID90423769
• Wikidata: Q82236054
• Mol file: 62143-51-5.mol

Synonyms:1-benzyl-4-phenylpiperidine-2,6-dione;62143-51-5;1-Benzyl-4-phenyl-piperidine-2,6-dione;2,6-Piperidinedione, 4-phenyl-1-(phenylmethyl)-;DTXSID90423769;QOUSZMRKBNBUCP-UHFFFAOYSA-N

Chemical Property of 1-Benzyl-4-phenylpiperidine-2,6-dione

Chemical Property:

• XLogP3: 2.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 279.125928785
• Heavy Atom Count: 21
• Complexity: 363

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1C(CC(=O)N(C1=O)CC2=CC=CC=C2)C3=CC=CC=C3

Technology Process of 1-Benzyl-4-phenylpiperidine-2,6-dione

There total 6 articles about 1-Benzyl-4-phenylpiperidine-2,6-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-phenylglutaric acid anhydride (4160-80-9) + benzylamine (100-46-9) → 1-(phenylmethyl)-4-phenylpiperidin-2,6-dione (62143-51-5)

Guidance literature:

3-phenylglutaric acid anhydride; benzylamine; With triethylamine; In tetrahydrofuran; Reflux;

With acetyl chloride; at 60 ℃;

DOI:10.1021/acs.joc.5b02177

Reference yield:

3-phenylglutaric acid (4165-96-2) + benzylamine (100-46-9) → 1-(phenylmethyl)-4-phenylpiperidin-2,6-dione (62143-51-5)

Guidance literature:

With 1,4-dioxane; at 250 ℃; under 110326 Torr; unter Wasserstoff;

Reference yield:

5-(benzylamino)-5-oxo-3-phenylpentanoic acid (92410-37-2) → 1-(phenylmethyl)-4-phenylpiperidin-2,6-dione (62143-51-5)

Guidance literature:

With acetyl chloride; at 65 ℃;

DOI:10.1021/ja067777y

upstream raw materials:

3-phenylglutaric acid anhydride

benzylamine

3-phenylglutaric acid

1,4-dioxane

Downstream raw materials:

1-(phenylmethyl)-4-phenylpiperidine

4-phenylpiperidine