2-[(2-methoxyphenyl)methyl]butanedioic acid

Base Information

• Chemical Name: 2-[(2-methoxyphenyl)methyl]butanedioic acid
• CAS No.: 32298-34-3
• Molecular Formula: C12H14O5
• Molecular Weight: 238.24
• Hs Code.: 2918990090
• Mol file: 32298-34-3.mol

Synonyms:Butanedioicacid, [(2-methoxyphenyl)methyl]- (9CI);NSC 10149;Succinic acid, (o-methoxy benzyl)-(7CI);

Chemical Property of 2-[(2-methoxyphenyl)methyl]butanedioic acid

Chemical Property:

• Vapor Pressure: 7.83E-06mmHg at 25°C
• Refractive Index: 1.554
• Boiling Point: 360.7 °C at 760 mmHg
• Flash Point: 135.3 °C
• PSA: 83.83000
• Density: 1.284 g/cm³
• LogP: 1.41320

Purity/Quality:

99% ^*data from raw suppliers

2-(2-METHOXY-BENZYL)-SUCCINIC ACID 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-[(2-methoxyphenyl)methyl]butanedioic acid

There total 7 articles about 2-[(2-methoxyphenyl)methyl]butanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.6%

2-(2-Methoxy-benzyl)-succinic acid diethyl ester → (2-methoxy benzyl) succinic acid (32298-34-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In acetic acid;

DOI:10.1080/00397919208020492

Reference yield: 40.0%

2-(2-Methoxy-benzyliden)-bernsteinsaeure (1144-98-5,24289-96-1) → (2-methoxy benzyl) succinic acid (32298-34-3)

Guidance literature:

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; at 20 ℃; for 5h;

DOI:10.1016/j.bmcl.2011.12.096

Reference yield:

ortho-anisaldehyde (135-02-4) → (2-methoxy benzyl) succinic acid (32298-34-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 47 percent / Na / ethanol / 2 h / Heating

2: 87.6 percent / H₂ / 10percent Pd/C / acetic acid

With hydrogen; sodium; palladium on activated charcoal; In ethanol; acetic acid;

DOI:10.1080/00397919208020492

upstream raw materials:

diethyl acetylsuccinate

o-Methoxybenzyl chloride

(2-methoxyphenyl)methanol

ortho-anisaldehyde

Downstream raw materials:

8-hydroxy-1,2,3,4-tetrahydro-naphthalene-2-carboxylic acid

8-Methoxy-(2R)-2-amino-1,2,3,4-tetrahydronaphthalene hydrochloride

(+/-)-8-OH-DPAT hydrobromide

8-methoxy-2-(di-n-propylamino)tetralin

Refernces

• 1、 Langlois,Gaudy. "A new synthesis of 8-hydroxy-2-di-n-propylamino-tetralin (8-OH-DPAT)". . p. 1723 - 1734. Retrieved 2007/10/02.