Benzenamine, 4-chloro-2-(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)-

Base Information

Chemical Name:Benzenamine, 4-chloro-2-(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)-
CAS No.:62206-12-6
Molecular Formula:C17H17ClN2O2
Molecular Weight:316.787
Hs Code.:
DSSTox Substance ID:DTXSID20486241
Wikidata:Q82326495

Synonyms:62206-12-6;4-CHLORO-2-(6,7-DIMETHOXY-3,4-DIHYDROISOQUINOLIN-1-YL)ANILINE;Benzenamine, 4-chloro-2-(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)-;DTXSID20486241

Suppliers and Price of Benzenamine, 4-chloro-2-(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Benzenamine, 4-chloro-2-(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)-

Chemical Property:

XLogP3:3.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:3
Exact Mass:316.0978555
Heavy Atom Count:22
Complexity:418

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=C(C=C2C(=C1)CCN=C2C3=C(C=CC(=C3)Cl)N)OC

Technology Process of Benzenamine, 4-chloro-2-(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)-

There total 6 articles about Benzenamine, 4-chloro-2-(3,4-dihydro-6,7-dimethoxy-1-isoquinolinyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 62206-13-7
6,7-dimethoxy-1-(5'-chloro-2'-nitrophenyl)-3,4-dihydroisoquinoline

: 2,3-dimethoxy-11-chloro-5,6-dihydroindazolo[3,2-a]isoquinoline

: 62206-12-6
4-chloro-2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)aniline

Guidance literature:: With tin(ll) chloride; In ethyl acetate; at 80 ℃; for 30h;
DOI:10.1002/jccs.200500135

Reference yield:

: 2516-95-2
5-chloro-2-nitrobenzoic acid

: 62206-12-6
4-chloro-2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)aniline

Guidance literature:: Multi-step reaction with 4 steps

1: thionyl chloride / benzene / 12 h / 70 - 75 °C

2: pyridine / benzene / 20 °C

3: POCl₃ / acetonitrile / Heating

4: SnCl₂*2H₂O / ethyl acetate / 30 h / Heating

With pyridine; thionyl chloride; tin(ll) chloride; trichlorophosphate; In ethyl acetate; acetonitrile; benzene; 3: Bischler-Napieralski reaction;
DOI:10.1016/j.ejmech.2006.03.011

Reference yield:

: 41994-44-9
5-chloro-2-nitrobenzoyl chloride

: 62206-12-6
4-chloro-2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)aniline

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / benzene / 20 °C

2: POCl₃ / acetonitrile / Heating

3: SnCl₂*2H₂O / ethyl acetate / 30 h / Heating

With pyridine; tin(ll) chloride; trichlorophosphate; In ethyl acetate; acetonitrile; benzene; 2: Bischler-Napieralski reaction;
DOI:10.1016/j.ejmech.2006.03.011