3-(Dimethylamino)propanohydrazide

Base Information

• Chemical Name: 3-(Dimethylamino)propanohydrazide
• CAS No.: 22636-79-9
• Molecular Formula: C5H13 N3 O
• Molecular Weight: 131.17886
• Hs Code.: 2928000090
• DSSTox Substance ID: DTXSID30368680
• Wikidata: Q82155413
• Mol file: 22636-79-9.mol

Synonyms:3-(dimethylamino)propanehydrazide;3-(dimethylamino)propanohydrazide;22636-79-9;SCHEMBL519337;DTXSID30368680;SYUSPJZZPLJCLO-UHFFFAOYSA-N;HMS1765J09;XAA63679;AC8035;MFCD04635439;N-Amino-3-(dimethylamino)propanamide;AKOS005267113;AS-77639;SY137573;BB 0258333;CS-0449914;FT-0682681;EN300-07733;Z56959747

Chemical Property of 3-(Dimethylamino)propanohydrazide

Chemical Property:

• Vapor Pressure: 0.00583mmHg at 25°C
• Boiling Point: 273.1°Cat760mmHg
• PKA: 13.32±0.18(Predicted)
• Flash Point: 119°C
• PSA: 58.36000
• Density: g/cm³
• LogP: 0.01920
• XLogP3: -0.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 131.105862047
• Heavy Atom Count: 9
• Complexity: 92.2

Purity/Quality:

97% ^*data from raw suppliers

3-(dimethylamino)propanohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)CCC(=O)NN

Technology Process of 3-(Dimethylamino)propanohydrazide

There total 2 articles about 3-(Dimethylamino)propanohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

methyl 3-(dimethylamino)propionate (3853-06-3) → 3-(dimethylamino)propanehydrazide (22636-79-9)

Guidance literature:

With hydrazine; In ethanol; water; Reflux;

DOI:10.1016/j.ejmech.2019.04.021

Reference yield:

ethyl 3-(N,N-dimethylamino)propionate (20120-21-2) → 3-(dimethylamino)propanehydrazide (22636-79-9)

Guidance literature:

With hydrazine hydrate; In ethanol;

DOI:10.1111/j.2042-7158.1964.tb07521.x

Reference yield: 50.0%

3-methoxy-N-methyl-4-nitrobenzamide (878160-13-5) + 3-(dimethylamino)propanehydrazide (22636-79-9) → 2-(5-(3-methoxy-4-nitrophenyl)-4-methyl-4H-1,2,4-triazol-3-yl)-N,N-dimethylethanamine

Guidance literature:

3-methoxy-N-methyl-4-nitrobenzamide; With thionyl chloride; In 1,2-dichloro-ethane; at 90 ℃; for 2h; Microwave irradiation;

3-(dimethylamino)propanehydrazide; In 1,2-dichloro-ethane; acetonitrile; at 110 ℃; for 1h; Inert atmosphere; Microwave irradiation;

DOI:10.1021/acs.jmedchem.8b00690

upstream raw materials:

methyl 3-(dimethylamino)propionate

ethyl 3-(N,N-dimethylamino)propionate