6-Chlorothieno[2,3-b]pyridine

Base Information

• Chemical Name: 6-Chlorothieno[2,3-b]pyridine
• CAS No.: 62226-18-0
• Molecular Formula: C7H4ClNS
• Molecular Weight: 169.63100
• Hs Code.: 2934999090
• European Community (EC) Number: 828-651-3
• DSSTox Substance ID: DTXSID20469791
• Wikidata: Q82297652
• Mol file: 62226-18-0.mol

Synonyms:6-Chlorothieno[2,3-b]pyridine;62226-18-0;Thieno[2,3-b]pyridine, 6-chloro-;SCHEMBL7215769;AMY7818;DTXSID20469791;FBLJMPADHWBVBA-UHFFFAOYSA-N;MFCD18253768;AKOS016005539;AS-59728;CS-0084705;C75923;EN300-261464

Chemical Property of 6-Chlorothieno[2,3-b]pyridine

Chemical Property:

• Melting Point: 57-58 °C(Solv: ethanol (64-17-5); water (7732-18-5))
• Boiling Point: 269.9±20.0 °C(Predicted)
• PKA: -0.55±0.30(Predicted)
• PSA: 41.13000
• Density: 1.435±0.06 g/cm3(Predicted)
• LogP: 2.94970
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 168.9752980
• Heavy Atom Count: 10
• Complexity: 131

Purity/Quality:

98%Min ^*data from raw suppliers

6-Chlorothieno[2,3-b]pyridine 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC2=C1C=CS2)Cl

Technology Process of 6-Chlorothieno[2,3-b]pyridine

There total 12 articles about 6-Chlorothieno[2,3-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

6-bromo-2-chlorothieno<2,3-b>pyridine (68236-35-1) → 6-chlorothieno[2,3-b]pyridine (62226-18-0)

Guidance literature:

6-bromo-2-chlorothieno<2,3-b>pyridine; With n-butyllithium; In diethyl ether; at -35 ℃;

With water; In diethyl ether;

DOI:10.1055/s-2006-926416

Reference yield: 32.0%

4,6-dichlorothieno<2,3-b>pyridine (99429-80-8) → 6-chlorothieno[2,3-b]pyridine (62226-18-0)

Guidance literature:

With acetic acid; zinc; for 48h; Ambient temperature;

Reference yield:

N-(5-bromothiophen-2-yl)acetamide (68236-26-0) → 6-chlorothieno[2,3-b]pyridine (62226-18-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 31 percent / POCl₃ / 1,1,2,2-tetrachloro-ethane / 125 °C

2.1: n-BuLi / diethyl ether / -35 °C

2.2: 85 percent / H₂O / diethyl ether

With n-butyllithium; trichlorophosphate; In diethyl ether; 1,1,2,2-tetrachloroethane;

DOI:10.1055/s-2006-926416

upstream raw materials:

7H-thieno[2,3-b]pyridin-6-one

7H-thieno[2,3-b]pyridin-4-one

6-bromo-2-chlorothieno<2,3-b>pyridine

4,6-dichlorothieno<2,3-b>pyridine