68236-26-0

Usage

Uses

Used in Pharmaceutical Industry:
N-(2-BROMOTHIOPHEN-5-YL)-ACETAMIDE is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its unique chemical structure allows it to be a versatile building block in the creation of new drugs, contributing to the advancement of medicinal chemistry.
Used in Agrochemical Industry:
In the agrochemical sector, N-(2-BROMOTHIOPHEN-5-YL)-ACETAMIDE serves as an essential intermediate in the production of agrochemicals. Its role in the synthesis of pesticides and other agricultural chemicals helps improve crop protection and yield.
Used in Organic Synthesis:
N-(2-BROMOTHIOPHEN-5-YL)-ACETAMIDE is used as a reagent in organic synthesis for the preparation of a wide range of organic compounds. Its functional groups and reactivity make it a valuable component in the synthesis of various organic molecules, expanding the scope of organic chemistry.
Used in Research and Development:
N-(2-BROMOTHIOPHEN-5-YL)-ACETAMIDE is utilized in research and development laboratories for the exploration of new chemical reactions and the synthesis of novel compounds. Its presence in the lab setting aids scientists in understanding its properties and potential applications, furthering the knowledge in the field of chemistry.

Upstream product

• 5370-25-2 2-Acetyl-5-bromothiophene 
• 74322-99-9 1-(5-bromothiophen-2-yl)ethanone oxime 
• 13195-50-1 2-bromo-5-nitrothiophene 
• 108-24-7 acetic anhydride 
• 98453-21-5 (1E)-1-(5-bromothiophen-2-yl)ethanone oxime 
• 943321-89-9 1,1-dimethylethyl (5-bromo-2-thienyl)carbamate 

Downstream Products

• 68236-35-1 6-bromo-2-chlorothieno<2,3-b>pyridine 
• 68236-39-5 6-bromo-2-phenylthiothieno<2,3-b>pyridine 
• 1599475-23-6 C₁₃H₇BrF₃NO₂S 
• 1599475-27-0 C₁₃H₈BrF₂NO₂S 
• 62226-18-0 6-chlorothieno[2,3-b]pyridine 

Relevant academic research and scientific papers

AMINOISOXAZOLINE COMPOUNDS AS AGONISTS OF ALPHA7-NICOTINIC ACETYLCHOLINE RECEPTORS

The present invention relates to novel aminoisoxazoline compounds, and pharmaceutical compositions of the same, that are suitable as agonists or partial agonists of α7-nAChR, and methods of preparing these compounds and compositions, and the use of these compounds and compositions in methods of maintaining, treating and/or improving cognitive function. In particular, methods of administering the compound or composition to a patient in need thereof, for example a patient with a cognitive deficiency and/or a desire to enhance cognitive function, that may derive a benefit therefrom.

The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases

The emergence of multidrug-resistant bacteria emphasizes the urgent need for novel antibacterial compounds targeting unique cellular processes. Two-component signal transduction systems (TCSs) are commonly used by bacteria to couple environmental stimuli

COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store -operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combinati

COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM

Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.

An efficient catalytic method for the Beckmann rearrangement of ketoximes to amides and aldoximes to nitriles mediated by propylphosphonic anhydride (T3P)

An efficient method for the Beckmann rearrangement of ketoximes to amides mediated by a catalytic amount (15 mol %) of propylphosphonic anhydride (T3P) is described. Aldoximes underwent second order Beckmann rearrangement to provide the corresponding nitriles in excellent yields on reacting with T3P (15 mol %) at room temperature. The main advantages of this environmentally friendly protocol include procedural simplicity, and particularly ease of isolation of the products.

Novel thienopyrrole glycogen phosphorylase inhibitors: Synthesis, in vitro SAR and crystallographic studies

Two series of novel thienopyrrole inhibitors of recombinant human liver glycogen phosphorylase a (GPa) which are effective in reducing glucose output from rat hepatocytes are described. Representative compounds have been shown to bind at the dimer interface site of the rabbit muscle enzyme by X-ray crystallography.

Synthesis of the fused heterobicycles 5-pyridin-2-yl-thieno[3,2-b]pyridine, 6-pyridin-2-yl-thieno[2,3-b]pyridine and 6-pyridin-2-yl-thieno[3,2-c]pyridine

Three new pyridyl thienopyridines, 5-pyridin-2-yl-thieno[3,2-b]pyridine, 6-pyridin-2-yl-thieno[2,3-b]pyridine and 6-pyridin-2-yl-thieno[3,2-c]pyridine, have been synthesized, each through a different synthetic sequence. Overall yields ranged from 8% to 32%. Georg Thieme Verlag Stuttgart.

E- and Z-Isomerism of 2-Acetylthiophene Oximes

A study of the oximation of a number of 2-acetylthiophenes in order to ascertain the validity of contradictory results previously described is reported.The fact that the steric hidrance is smaller in 2-acetylthiophenes unsubstituted at position-3 than in acetylbenzenes allows in these cases the formation of Z-oximes, which even can predominate on the E oximes in the case of a +M substitution at position-5.In the paper is also shown that the E/Z ratio of 2-acetylthiophene oximes can be deduced from 1H-nmr spectrum of the crude reaction mixture.