2-(2-Methoxyphenoxy)benzaldehyde

Base Information

• Chemical Name: 2-(2-Methoxyphenoxy)benzaldehyde
• CAS No.: 62256-40-0
• Molecular Formula: C14H12O3
• Molecular Weight: 228.247
• DSSTox Substance ID: DTXSID60486826
• Wikidata: Q82328324
• Mol file: 62256-40-0.mol

Synonyms:2-(2-methoxyphenoxy)benzaldehyde;62256-40-0;SCHEMBL2074740;DTXSID60486826;LXJAXYDYHJZNPW-UHFFFAOYSA-N;2-(2-methoxy-phenoxy)-benzaldehyde;AKOS000260556;F78992

Chemical Property of 2-(2-Methoxyphenoxy)benzaldehyde

Chemical Property:

• PSA: 35.53000
• LogP: 3.30000
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 228.078644241
• Heavy Atom Count: 17
• Complexity: 242

Purity/Quality:

95%-98% ^*data from raw suppliers

2-(2-Methoxyphenoxy)benzaldehyde 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=CC=C1OC2=CC=CC=C2C=O

Technology Process of 2-(2-Methoxyphenoxy)benzaldehyde

There total 2 articles about 2-(2-Methoxyphenoxy)benzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

2-Fluorobenzaldehyde (446-52-6) + 2-methoxy-phenol (90-05-1) → 2-(2-methoxyphenoxy)benzaldehyde (62256-40-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl acetamide; at 170 ℃; for 6h; Inert atmosphere;

DOI:10.1002/adsc.201300488

Reference yield:

2-bromoanisole (578-57-4) → 2-(2-methoxyphenoxy)benzaldehyde (62256-40-0)

Guidance literature:

at 210 - 220 ℃;

DOI:10.1021/ja01166a128

Reference yield: 78.0%

2-(2-methoxyphenoxy)benzaldehyde (62256-40-0) → 4-methoxy-9H-xanthen-9-one (6702-58-5)

Guidance literature:

With tert.-butylhydroperoxide; tetrabutylammomium bromide; In water; at 120 ℃; for 24h; Schlenk technique; Sealed tube;

DOI:10.1002/adsc.201300488

upstream raw materials:

2-Fluorobenzaldehyde

2-methoxy-phenol

2-bromoanisole

Downstream raw materials:

2-carboxy-2'-methoxydiphenyl ether

2-(2-methoxyphenoxy)-α-hydroxybenzeneacetic acid

2-(2-hydroxyphenoxy)-α-bromobenzeneacetic acid

methyl 2-(2-hydroxyphenoxy)-α-bromobenzeneacetate

Refernces

• 1、 Melloni,Della Torre,Meroni,Pevarello,Varasi,Bonsignori,Cini,Vaghi,Dostert. "Synthesis of new fenmetazole analogues with potential mixed α2-adrenergic antagonistic activity and noradrenaline-uptake inhibiting properties". . p. 207 - 213. Retrieved 2007/10/02.