o-Iodophenylacetyl chloride

Base Information

• Chemical Name: o-Iodophenylacetyl chloride
• CAS No.: 62300-07-6
• Molecular Formula: C8H6ClIO
• Molecular Weight: 280.493
• DSSTox Substance ID: DTXSID30448956
• Nikkaji Number: J1.162.373E
• Wikidata: Q82268193
• Mol file: 62300-07-6.mol

Synonyms:62300-07-6;o-iodophenylacetyl chloride;(2-Iodophenyl)acetyl chloride;2-(2-iodophenyl)acetyl Chloride;(2-Iodophenyl)acetyl choride;2-iodophenylacetylchloride;2-iodophenylacetyl chloride;SCHEMBL3259050;(2-Iodo-phenyl)-acetyl chloride;2-Iodobenzeneacetic acid chloride;DTXSID30448956;ZNOGBAPLEYMVSS-UHFFFAOYSA-N;MFCD12025057

Chemical Property of o-Iodophenylacetyl chloride

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 279.91519
• Heavy Atom Count: 11
• Complexity: 149

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C(=C1)CC(=O)Cl)I

Technology Process of o-Iodophenylacetyl chloride

There total 4 articles about o-Iodophenylacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

o-iodophenylacetic acid (18698-96-9) → o-iodophenylacetyl chloride (62300-07-6)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 ℃; for 3h; Inert atmosphere;

Reference yield:

2-(2-iodophenyl)acetonitrile (40400-15-5) → o-iodophenylacetyl chloride (62300-07-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 87 percent / NaOH / ethanol; H₂O / 6.5 h / Heating

2: 2.60 g / SOCl₂ / 12 h / Ambient temperature

With sodium hydroxide; thionyl chloride; In ethanol; water;

DOI:10.1021/jo9901900

Reference yield:

2-(chloromethyl)iodobenzene (59473-45-9) → o-iodophenylacetyl chloride (62300-07-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / dimethylsulfoxide / 70 °C

2: 87 percent / NaOH / ethanol; H₂O / 6.5 h / Heating

3: 2.60 g / SOCl₂ / 12 h / Ambient temperature

With sodium hydroxide; thionyl chloride; In ethanol; water; dimethyl sulfoxide;

DOI:10.1021/jo9901900

upstream raw materials:

o-iodophenylacetic acid

2-(2-iodophenyl)acetonitrile

2-(chloromethyl)iodobenzene

(2-iodophenyl)diazomethyl ketone

Downstream raw materials:

1-(2-iodophenyl)propan-2-one

2-(2-iodophenyl)-N-methoxyacetamide

2-(2-iodophenyl)-N-methoxy-N-methylacetamide

N.N'-Bis-<2-jod-benzoyl>-hydrazin