59473-45-9

Basic information

• Product Name: 2-Iodobenzyl chloride
• Synonyms: 1-(Chloromethyl)-2-iodobenzene;Benzene, 1-(chloromethyl)-2-iodo-;2-IODOBENZYL CHLORIDE;ALPHA-CHLORO-2-IODOTOLUENE;o-Iodobenzylchloride;1-Iodo-2-(chloromethyl)benzene;Einecs 261-779-2;2-Iodobenzyl chloride 98%
• CAS NO: 59473-45-9
• Molecular Formula: C₇H₆ClI
• Molecular Weight: 252.48
• EINECS: 261-779-2
• Product Categories: Aryl;C7;Halogenated Hydrocarbons
• Mol File: 59473-45-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: 29-31 °C(lit.)
• Boiling Point: 147-149 °C32 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.7773 (estimate)
• Vapor Pressure: 0.0246mmHg at 25°C
• Refractive Index: n20/D 1.635(lit.)
• CAS DataBase Reference: 2-Iodobenzyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Iodobenzyl chloride(59473-45-9)
• EPA Substance Registry System: 2-Iodobenzyl chloride(59473-45-9)

Safety Data

• Hazard Codes: C
• Statements: 34-36/37
• Safety Statements: 26-27-28-36/37/39-45
• RIDADR: UN 3261 8/PG 2
• WGK Germany: 3
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 59473-45-9(Hazardous Substances Data)

Usage

Uses

2-Iodobenzyl chloride was used in the synthesis of:succinimido[3,4-b]indane1,2,3,4,5,6-hexahydro-1,5-methano-3-benzazocine-2,4-dione1-(2-iodobenzyi)-1,1-diethylamine1-(2-iodobenzyl)pyrrolidine1-(2-iodobenzyl)piperidine1-(2-iodobenzyl)hexahydroazepine4-(2-iodobenzyl)morpholine4-(2-iodobenzyl)thiomorpholine1-benzoyl-4-(2-iodobenzyl)piperazine1-(2-iodobenzyl)indole-2-carbaldehyde

InChI:InChI=1/C7H6ClI/c8-5-6-3-1-2-4-7(6)9/h1-4H,5H2

Upstream product

• 10026-13-8 phosphorus pentachloride 
• 5159-41-1 2-iodobenzyl alcohol 
• 183789-20-0 2-iodobenzyl methanesulfonate 
• 463-79-6 carbonic-acid 
• 124-63-0 methanesulfonyl chloride 
• 52470-94-7 (2-iodophenyl)diazomethyl ketone 
• 18698-96-9 o-iodophenylacetic acid 
• 62300-07-6 o-iodophenylacetyl chloride 
• 40400-13-3 2-Iodobenzyl bromide 
• 103-83-3 N,N'-dimethylbenzylamine 
• 88-67-5 2-Iodobenzoic acid 
• 101290-83-9 Bis-<2-jod-phenylacetyl>-peroxid 
• 10175-33-4 1-(2-iodophenyl)-N,N-dimethylmethanamine 
• 75-62-7 Bromotrichloromethane 

Downstream Products

• 138154-61-7 2-(pyrrolidin-1-ylmethyl)phenyl iodide 
• 76464-88-5 2-(piperidin-1-ylmethyl)phenyl iodide 
• 156333-96-9 1-formyl-4-(2-iodobenzyl)piperazine 
• 155912-06-4 1-(2-iodobenzyl)indole-2-carbaldehyde 
• 128638-84-6 3-(2-chloromethylphenyl)-cyclohexanone 
• 157099-90-6 N-(hex-5-enyl)-N-(2-iodobenzyl)acetamide 
• 111373-31-0 diethyl (2-iodobenzyl)malonate 
• 40400-15-5 2-(2-iodophenyl)acetonitrile 
• 73038-47-8 2-[(phenylthio)methyl]-1-iodobenzene 
• 128666-75-1 (1S,4R)-4-(t-butyldiphenylsilyloxy)-1-(1-chloromethyl-2-phenyl)-2-phenylsulfonylcyclopent-2-ene 
• 157099-92-8 N-(hex-5-enyl)-N-(2-iodobenzyl)benzamide 
• 137092-31-0 Dithiopivalinsaeure-2-iodbenzylester 
• 106130-20-5 <1-(14)C>(o-iodophenyl)acetonitrile 
• 10175-33-4 1-(2-iodophenyl)-N,N-dimethylmethanamine 

Relevant articles and documents

MACROCYCLIC COMPOUNDS USEFUL AS CHITINASE INHIBITORS

The present invention relates to macrocyclic compounds of formula (I) and their use as chitinase inhibitors as well as to pharmaceutical compositions and methods of preparation thereof. The compounds can in particular be used in the treatment, prevention and/or amelioration of asthma.

Formamides as Lewis Base Catalysts in SNReactions—Efficient Transformation of Alcohols into Chlorides, Amines, and Ethers

A simple formamide catalyst facilitates the efficient transformation of alcohols into alkyl chlorides with benzoyl chloride as the sole reagent. These nucleophilic substitutions proceed through iminium-activated alcohols as intermediates. The novel method, which can be even performed under solvent-free conditions, is distinguished by an excellent functional group tolerance, scalability (>100 g) and waste-balance (E-factor down to 2). Chiral substrates are converted with excellent levels of stereochemical inversion (99 %→≥95 % ee). In a practical one-pot procedure, the primary formed chlorides can be further transformed into amines, azides, ethers, sulfides, and nitriles. The value of the method was demonstrated in straightforward syntheses of the drugs rac-Clopidogrel and S-Fendiline.

Cu-Catalyzed Suzuki-Miyaura reactions of primary and secondary benzyl halides with arylboronates

A copper-catalyzed Suzuki-Miyaura coupling of benzyl halides with arylboronates is described. Varieties of primary benzyl halides as well as more challenging secondary benzyl halides with β hydrogens or steric hindrance could be successfully converted into the corresponding products. Thus it provides access to diarylmethanes, diarylethanes and triarylmethanes. This journal is the Partner Organisations 2014.