5-(3-Chlorophenyl)-5-hydroxy-1-methyl-2-pyrrolidinone

Base Information

Chemical Name:5-(3-Chlorophenyl)-5-hydroxy-1-methyl-2-pyrrolidinone
CAS No.:93040-74-5
Molecular Formula:C11H12ClNO2
Molecular Weight:225.6715
Hs Code.:
DSSTox Substance ID:DTXSID00918757
ChEMBL ID:CHEMBL106353

Synonyms:BRN 6507840;5-(3-Chlorophenyl)-5-hydroxy-1-methyl-2-pyrrolidinone;2-Pyrrolidinone, 5-(3-chlorophenyl)-5-hydroxy-1-methyl-;93040-74-5;5-(3-chlorophenyl)-5-hydroxy-1-methylpyrrolidin-2-one;CHEMBL106353;DTXSID00918757;LS-138670

Suppliers and Price of 5-(3-Chlorophenyl)-5-hydroxy-1-methyl-2-pyrrolidinone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 0 raw suppliers

Chemical Property of 5-(3-Chlorophenyl)-5-hydroxy-1-methyl-2-pyrrolidinone

Chemical Property:

Vapor Pressure:7.23E-08mmHg at 25°C
Boiling Point:421.8°Cat760mmHg
Flash Point:208.9°C
Density:1.344g/cm³
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:1
Exact Mass:225.0556563
Heavy Atom Count:15
Complexity:271

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN1C(=O)CCC1(C2=CC(=CC=C2)Cl)O

Technology Process of 5-(3-Chlorophenyl)-5-hydroxy-1-methyl-2-pyrrolidinone

There total 2 articles about 5-(3-Chlorophenyl)-5-hydroxy-1-methyl-2-pyrrolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1121-07-9
N-methylsuccinimide

: 36229-42-2
(3-chlorophenyl)magnesium bromide

: 93040-74-5
5-(3-chlorophenyl)-5-hydroxy-1-methylpyrrolidin-2-one

Guidance literature:: In tetrahydrofuran; at -20 ℃; for 12h; Autoclave; Inert atmosphere;
DOI:10.1021/acs.orglett.7b00651

Reference yield:

: 1121-07-9
N-methylsuccinimide

: 108-37-2
1-bromo-3-chlorobenzene

: 93040-74-5
5-(3-chlorophenyl)-5-hydroxy-1-methylpyrrolidin-2-one

Guidance literature:: With magnesium; Yield given. Multistep reaction; 1.) Et₂O, reflux, 1 h, 2.) Et₂O, C₆H₆, reflux, 4 h;
DOI:10.1021/jm00379a007