N-(2,4-dichloro-6-nitro-phenyl)acetamide

Base Information

• Chemical Name: N-(2,4-dichloro-6-nitro-phenyl)acetamide
• CAS No.: 65078-75-3
• Molecular Formula: C8H6 Cl2 N2 O3
• Molecular Weight: 249.053
• Hs Code.: 2924299090
• Mol file: 65078-75-3.mol

Synonyms:Acetanilide,2',4'-dichloro-6'-nitro- (7CI); NSC 55644

Chemical Property of N-(2,4-dichloro-6-nitro-phenyl)acetamide

Chemical Property:

• Vapor Pressure: 1.24E-06mmHg at 25°C
• Boiling Point: 400.8°C at 760 mmHg
• Flash Point: 196.2°C
• PSA: 74.92000
• Density: 1.573g/cm³
• LogP: 3.45620

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2,4-dichloro-6-nitro-phenyl)acetamide

There total 6 articles about N-(2,4-dichloro-6-nitro-phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.2%

o-nitroacetanilide (552-32-9) → N-(2,4-dichloro-6-nitrophenyl)acetamide (65078-75-3)

Guidance literature:

With N-chloro-N-(benzenesulfonyl)benzenesulfonamide; In acetonitrile; at 20 - 25 ℃; for 0.166667h; Green chemistry;

DOI:10.1016/j.tetlet.2020.152689

Reference yield: 73.0%

N-(2,4-dichlorophenyl)acetamide (6975-29-7) → N-(2,4-dichloro-6-nitrophenyl)acetamide (65078-75-3)

Guidance literature:

With sulfuric acid; nitric acid; at 20 ℃;

Reference yield: 56.0%

acetic anhydride (108-24-7) + 2,4-Dichloroaniline (554-00-7,51908-09-9) → N-(2,4-dichloro-6-nitrophenyl)acetamide (65078-75-3)

Guidance literature:

With bismuth (III) nitrate pentahydrate; In dichloromethane; at 23 ℃; regioselective reaction;

DOI:10.1016/j.tet.2013.08.076

upstream raw materials:

N-(2,4-dichlorophenyl)acetamide

acetic anhydride

2,4-Dichloroaniline

2,4-dichloro-6-nitroaniline

Downstream raw materials:

2,4-dichloro-6-nitroaniline

N-(2,4-Dichloro-6-{[1-(2-nitro-phenyl)-meth-(Z)-ylidene]-amino}-phenyl)-acetamide

2-amino-4,6-dichloroacetanilide

Refernces

• 1、 Lu, Yang,Li, Yaming,Zhang, Rong,Jin, Kun,Duan, Chunying. "Regioselective ortho-nitration of N-phenyl carboxamides and primary anilines using bismuth nitrate/acetic anhydride". supporting information. p. 9422 - 9427. Retrieved 2013/10/08.