4-Oxazolecarbonyl chloride, 2-methyl- (9CI)

Base Information

• Chemical Name: 4-Oxazolecarbonyl chloride, 2-methyl- (9CI)
• CAS No.: 62348-22-5
• Molecular Formula: C5H4ClNO2
• Molecular Weight: 145.54400
• Hs Code.: 2934999090
• Mol file: 62348-22-5.mol

Synonyms:2-methyl-1,3-oxazole-4-carboxylic acid chloride;4-Oxazolecarbonyl chloride,2-methyl;2-METHYL-4-OXAZOLECARBONYL CHLORIDE;2-methyloxazole-4-carboxylic acid chloride;2-methyloxazole-4-carbonyl chloride;

Chemical Property of 4-Oxazolecarbonyl chloride, 2-methyl- (9CI)

Chemical Property:

• PSA: 43.10000
• LogP: 1.36200

Purity/Quality:

2-Methyl-1,3-oxazole-4-carbonyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Oxazolecarbonyl chloride, 2-methyl- (9CI)

There total 4 articles about 4-Oxazolecarbonyl chloride, 2-methyl- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

2-methyl-1,3-oxazol-4-carboxylic acid (23012-17-1) → 2-methyl-1,3-oxazole-4-carboxylic acid chloride (62348-22-5)

Guidance literature:

With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; at 0 - 20 ℃; for 4h; Inert atmosphere;

Reference yield:

2-methyl-4-carbethoxy-1,3-oxazole (10200-43-8) → 2-methyl-1,3-oxazole-4-carboxylic acid chloride (62348-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1: water; sodium hydroxide / 1 h / 20 - 25 °C / Large scale

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C

With oxalyl dichloride; water; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane;

DOI:10.1021/op700198s

Reference yield:

2-methyl-oxazole-4-carboxylic acid methyl ester (85806-67-3) → 2-methyl-1,3-oxazole-4-carboxylic acid chloride (62348-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / water / 2.25 h / 0 - 20 °C

2: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; N,N-dimethyl-formamide; sodium hydroxide; In dichloromethane; water;

DOI:10.1002/ejoc.201700020

upstream raw materials:

2-methyl-1,3-oxazol-4-carboxylic acid

2-Methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid ethyl ester

2-methyl-4-carbethoxy-1,3-oxazole

2-methyl-oxazole-4-carboxylic acid methyl ester

Downstream raw materials:

2-Methyloxazole-4-carboxamide

2''-Methyl-4-phenylselenyl-4,5-dihydro-2,4':2',4''-teroxazole-4-carboxylic acid methyl ester

2'-Methyl-4-phenylselenyl-4,5-dihydro-2,4'-bi(1,3-oxazoyl)-4-carboxylic acid methyl ester

2'-Methyl-2,4'-bi(1,3-oxazoyl)-4-carboxylic acid methyl ester

Refernces

• 1、 -. "IRAK DEGRADERS AND USES THEREOF". Paragraph 00920; 002780-002782. . Retrieved 2021/01/23.
• 2、 -. "SUBSTITUTED AZOANTHRACENE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF USE THEREOF". Page/Page column 373-374. . Retrieved 2010/11/03.