10200-43-8

Basic information

• Product Name: 2-methyl oxazole 4-ethyl ester
• Synonyms: ETHYL-4-METHYL-3,5-OXAZOLECARBOXYLATE;2-methyl oxazole 4-ethyl ester;2-Methyl-4-oxazolecarboxylic acid ethyl ester;Ethyl 2-methyl-4-oxazolecarboxylate;4-(Ethoxycarbonyl)-2-methyl-1,3-oxazole;Ethyl 2-methyl-1,3-oxazole-4-carboxylate;2-Methyl-oxazole-4-carboxylic acid ethyl ester
• CAS NO: 10200-43-8
• Molecular Formula: C₇H₉NO₃
• Molecular Weight: 155.15
• Mol File: 10200-43-8.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 210.361 °C at 760 mmHg
• Flash Point: 81.023 °C
• Appearance: /
• Density: 1.14 g/cm³
• Vapor Pressure: 0.193mmHg at 25°C
• Refractive Index: 1.468
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 2-methyl oxazole 4-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-methyl oxazole 4-ethyl ester(10200-43-8)
• EPA Substance Registry System: 2-methyl oxazole 4-ethyl ester(10200-43-8)

Safety Data

• Hazardous Substances Data: 10200-43-8(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C7H9NO3/c1-3-10-7(9)6-4-11-5(2)8-6/h4H,3H2,1-2H3

Upstream product

• 74-88-4 methyl iodide 
• 60-35-5 acetamide 
• 70-23-5 ethyl Bromopyruvate 
• 23012-14-8 oxazole-4-carboxylic acid ethyl ester 
• 142-71-2 copper diacetate 
• 68683-04-5 ethyl (2-methyl-2-oxazolin-4-yl)carboxylate 
• 7787-70-4 copper(I) bromide 
• 617-35-6 2-oxo-propionic acid ethyl ester 
• 108-24-7 acetic anhydride 
• 61999-29-9 2-Methyl-4,5-dihydro-1,3-oxazole-4-carboxylic acid ethyl ester 
• 14762-48-2 ethyl 2-diazo-3-oxo-propanoate 
• 75-05-8 acetonitrile 
• 109-94-4 formic acid ethyl ester 

Downstream Products

• 141567-53-5 4-hydroxymethyl-2-methyloxazole 
• 113732-84-6 2-methyl-1,3-oxazole-4-carbaldehyde 
• 875553-59-6 N-methoxy-N-methyl-2-methyloxazole-4-carboxamide 
• 100872-45-5 4-[4-(4-methoxy-phenyl)-thiazol-2-yl]-2-methyl-oxazole 
• 96461-28-8 2-methyl-4-[4-(4-nitro-phenyl)-thiazol-2-yl]-oxazole 
• 96462-75-8 4-[4-(4-bromo-phenyl)-thiazol-2-yl]-2-methyl-oxazole 
• 96583-11-8 4-[4-(4-chloro-phenyl)-thiazol-2-yl]-2-methyl-oxazole 
• 100872-18-2 2-methyl-4-(4-p-tolyl-thiazol-2-yl)-oxazole 
• 106166-86-3 2-methyl-4-(4-phenyl-thiazol-2-yl)-oxazole 
• 90980-10-2 2-methyl-oxazole-4-carbothioic acid amide 
• 89282-09-7 2-methyl-4-oxazolecarbonitrile 
• 139631-17-7 (2S,4S,5S,7E,9E,11E)-4-((tert-Butyldiphenylsilyl)oxy)-1,2-(isopropylidenedioxy)-5,7,11-trimethyl-12-(2'-methyloxazol-4'-yl)-7,9,11-dodecatrien-6-one 
• 139631-17-7 (5Z,7E,9E)-(2S,3S)-2-(tert-Butyl-diphenyl-silanyloxy)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-3,5,9-trimethyl-10-(2-methyl-oxazol-4-yl)-deca-5,7,9-trien-4-one 
• 139630-91-4 (E)-2-methyl-3-(2-methyloxazol-4-yl)acrylaldehyde 

Relevant articles and documents

DIRECT PREPARATION OF 4-CARBOETHOXY-1,3-OXAZOLES

The diazoaldehyde ester N2C(CHO)CO2Et undergoes rhodium-catalyzed reaction with nitriles to give 4-carboethoxy-1,3-oxazoles directly.

Facile synthesis of oxazoles starting from ketones

A new and efficient method for the preparation of 2,4- and 2,4,5-substituted oxazoles is described which is based upon the reaction of α-sulfonyloxy ketone intermediates with acetamide or benzamide.

Direct palladium-catalyzed alkenylation, benzylation and alkylation of ethyl oxazole-4-carboxylate with alkenyl-, benzyl- and alkyl halides

The ethyl oxazole-4-carboxylate was directly and regioselectively alkenylated, benzylated and alkylated with alkenyl-, benzyl-, allyl- and alkyl halides in the presence of catalytic amounts of palladium acetate with caesium carbonate using Buchwald's John

BENZAZEPINE DERIVATIVES, PROCESS FOR THE PREPARATION OF THE SAME AND USES THEREOF

Compounds of the general formula (I): or salts thereof, which exhibit CCR5 antagonism and exert preventive and therapeutic effects against HIV infections: wherein R1 is a 5- to 6-membered aromatic ring which bears a substituent represented by the general formula: R-Z1-X-Z2- (wherein R1 is hydrogen or optionally substituted hydrocarbyl; X is optionally substituted alkylene; and Z1 and Z2 are each a heteroatom) and may be further substituted, with R being optionally bonded to the aromatic ring to form another ring; Y is optionally substituted imino; and R2 and R3 are each optionally substituted aliphatic hydrocarbyl or an optionally substituted hetero-alicyclic group.