2-METHYL-6-QUINOLINECARBONITRILE

Base Information

• Chemical Name: 2-METHYL-6-QUINOLINECARBONITRILE
• CAS No.: 73013-69-1
• Molecular Formula: C11H8N2
• Molecular Weight: 168.198
• Hs Code.: 2933499090
• Mol file: 73013-69-1.mol

Synonyms:2-Methyl-6-quinolinecarbonitrile;6-cyano-2-quinaldine;2-Methyl-6-chinolincarbonitril;2-methyl-quinoline-6-carbonitrile;

Chemical Property of 2-METHYL-6-QUINOLINECARBONITRILE

Chemical Property:

• Vapor Pressure: 0.000255mmHg at 25°C
• Melting Point: 172-174℃ (methanol )
• Boiling Point: 323.9°Cat760mmHg
• Flash Point: 115.6°C
• PSA: 36.68000
• Density: 1.17g/cm³
• LogP: 2.41488

Purity/Quality:

98.5% ^*data from raw suppliers

2-Methylquinoline-6-carbonitrile 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-METHYL-6-QUINOLINECARBONITRILE

There total 2 articles about 2-METHYL-6-QUINOLINECARBONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

zinc(II) cyanide (557-21-1) + 6-Bromo-2-methyl-quinoline (877-42-9) → 2-methylquinoline-6-carbonitrile (73013-69-1)

Guidance literature:

With [(2-di-tert-butylphosphino-2′,4′,6′-triisopropyl-1, 1′-biphenyl)-2-(2′-amino-1,1′-biphenyl)] palladium(II) methanesulfonate; In tetrahydrofuran; water; at 40 ℃; for 18h; Inert atmosphere;

DOI:10.1021/ol5032359

Reference yield: 75.0%

6-Bromo-2-methyl-quinoline (877-42-9) + copper(I) cyanide (544-92-3) → 2-methylquinoline-6-carbonitrile (73013-69-1)

Guidance literature:

With pyridine; at 200 ℃; for 24h;

DOI:10.1021/ol048411y

Reference yield: 56.0%

2-methylphenyl bromide (95-46-5) + 2-methylquinoline-6-carbonitrile (73013-69-1) → 2-(2-methyl-benzyl)-quinoline-6-carbonitrile (1256347-72-4)

Guidance literature:

With bis(3,5,3′,5′-dimethoxydibenzylideneacetone)palladium(0); caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 100 ℃; for 16h; Inert atmosphere;

DOI:10.1021/ol102276e

upstream raw materials:

6-Bromo-2-methyl-quinoline

copper(I) cyanide

zinc(II) cyanide

Downstream raw materials:

2-(2-methyl-benzyl)-quinoline-6-carbonitrile

Refernces

• 1、 Jyothish, Kuthanapillil,Arun, Kalliat T.,Ramaiah, Danaboyina. "Synthesis of novel quinaldine-based squaraine dyes: Effect of substituents and role of electronic factors". . p. 3965 - 3968. Retrieved 2007/10/03.