8H-Imidazo[2,1-c][1,4]oxazine-2-carboxaldehyde, 5,6-dihydro- (9CI)

Base Information

• Chemical Name: 8H-Imidazo[2,1-c][1,4]oxazine-2-carboxaldehyde, 5,6-dihydro- (9CI)
• CAS No.: 623564-42-1
• Molecular Formula: C7H8N2O2
• Molecular Weight: 152.153
• Hs Code.: 2934999090
• Mol file: 623564-42-1.mol

Synonyms:8H-Imidazo[2,1-c][1,4]oxazine-2-carboxaldehyde, 5,6-dihydro- (9CI);5,6-Dihydro-8H-imidazo[2,1-c][1,4]oxazine-2-carboxaldehyde;5,6-dihydro- (9CI);6,8-Dihydro-5H-imidazo[2,1-c]-[1,4]oxazine-2-carbaldehyde

Chemical Property of 8H-Imidazo[2,1-c][1,4]oxazine-2-carboxaldehyde, 5,6-dihydro- (9CI)

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.646
• Boiling Point: 413.696 °C at 760 mmHg
• Flash Point: 203.996 °C
• PSA: 44.12000
• Density: 1.417 g/cm³
• LogP: 0.22580
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

6,8-Dihydro-5H-imidazo[2,1-c][1,4]oxazine-2-carbaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8H-Imidazo[2,1-c][1,4]oxazine-2-carboxaldehyde, 5,6-dihydro- (9CI)

There total 7 articles about 8H-Imidazo[2,1-c][1,4]oxazine-2-carboxaldehyde, 5,6-dihydro- (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

C9H12N2O3 (1096418-58-4) → 6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazine-2-carbaldehyde (623564-42-1)

Guidance literature:

C₉H₁₂N₂O₃; With diisobutylaluminium hydride; In tetrahydrofuran; at -78 - 40 ℃; for 3h;

With water; ammonium chloride; In tetrahydrofuran; Product distribution / selectivity;

Reference yield: 36.3%

morpholin-3-ylideneamine hydrochloride (623564-41-0) → 6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazine-2-carbaldehyde (623564-42-1) + 5,6-dihydro-8H-imidazo[2,1-c]oxazine-2-carbaldehyde (623564-43-2)

Guidance literature:

2-bromo-3-hydroxypropenal; With toluene-4-sulfonic acid; isopropyl alcohol; In cyclohexane; at 80 ℃;

morpholin-3-ylideneamine hydrochloride; With sodium methylate; In methanol; ethanol; at 20 ℃; for 2h;

With triethylamine; In chloroform; for 2h; Heating / reflux;

Reference yield: 36.3%

morpholin-3-ylideneamine hydrochloride (623564-41-0) + 2-bromo-3-hydroxypropenal (19263-02-6) → 6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazine-2-carbaldehyde (623564-42-1) + 5,6-dihydro-8H-imidazo[2,1-c]oxazine-2-carbaldehyde (623564-43-2)

Guidance literature:

2-bromo-3-hydroxypropenal; With toluene-4-sulfonic acid; In cyclohexane; isopropyl alcohol; at 80 ℃;

morpholin-3-ylideneamine hydrochloride; With sodium methylate; In methanol; ethanol; at 20 ℃; for 2h;

With triethylamine; In chloroform; for 2h; Heating / reflux;

upstream raw materials:

morpholin-3-ylideneamine hydrochloride

2-bromo-3-(1-methylethoxy)-2-propenal

morpholin-3-ylideneamine

C₉H₁₂N₂O₃

Downstream raw materials:

(5R)-6-[acetoxy-(5,6-dihydro-8H-imidazo[2,1-c][1,4]oxazin-2-yl)methyl]-6-bromo-7-oxo-4-thia-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid para-nitrobenzyl ester

C₂₀H₁₇BrN₄O₇S

2-(6,8-dihydro-5H-imidazo[2,1-c][1,4]oxazin-2-yl)-1-(1H-indol-3-yl)-2-((3-methoxyphenyl)amino)ethanone

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