1,3-Piperazinedicarboxylic acid, 1-[(4-nitrophenyl)methyl] ester

Base Information

• Chemical Name: 1,3-Piperazinedicarboxylic acid, 1-[(4-nitrophenyl)methyl] ester
• CAS No.: 623565-10-6
• Molecular Formula: C13H15N3O6
• Molecular Weight: 309.279
• Mol file: 623565-10-6.mol

Synonyms:

Chemical Property of 1,3-Piperazinedicarboxylic acid, 1-[(4-nitrophenyl)methyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,3-Piperazinedicarboxylic acid, 1-[(4-nitrophenyl)methyl] ester

There total 3 articles about 1,3-Piperazinedicarboxylic acid, 1-[(4-nitrophenyl)methyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

piperazine-2-carboxylic acid dihydrochloride (3022-15-9,126330-90-3,133525-05-0,135841-26-8) + 4-nitrobenzyl chloroformate (4457-32-3) → piperazine-1,3-dicarboxylic acid 1-(4-nitrobenzyl)ester (623565-10-6)

Guidance literature:

piperazine-2-carboxylic acid dihydrochloride; In water; for 0.166667h; Heating;

4-nitrobenzyl chloroformate; With sodium hydrogencarbonate; In 1,4-dioxane; water; at 0 ℃; for 1.5h;

DOI:10.1021/jm060021p

Reference yield: 77.0%

CuCO3.Cu(OH)2.H2O + piperazine-2-carboxylic acid dihydrochloride (3022-15-9,126330-90-3,133525-05-0,135841-26-8) + edetate disodium (139-33-3) + 4-nitrobenzyl chloroformate (4457-32-3) → piperazine-1,3-dicarboxylic acid 1-(4-nitrobenzyl)ester (623565-10-6)

Guidance literature:

With hydrogenchloride; sodium hydrogencarbonate; In 1,4-dioxane; water;

Reference yield: 77.0%

4-nitrobenzyl chloroformate (4457-32-3) → piperazine-1,3-dicarboxylic acid 1-(4-nitrobenzyl)ester (623565-10-6)

Guidance literature:

piperazine-2-carboxylic acid dihydrochloride; With copper (II) carbonate hydroxide; In water; for 0.166667h; Heating / reflux;

4-nitrobenzyl chloroformate; With sodium hydrogencarbonate; In 1,4-dioxane; water; at 0 ℃; for 1.5h;

With hydrogenchloride; In water; at 20 ℃; for 2.5h;

upstream raw materials:

piperazine-2-carboxylic acid dihydrochloride

4-nitrobenzyl chloroformate

edetate disodium

Downstream raw materials:

2-formyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylic acid 4-nitrobenzyl ester

5-(4-nitrobenzyloxycarbonyl)-3-oxo-3a,4,6,7-tetrahydro-3H-2-oxa-1,5-diaza-7a-azoniainden-3a-ide

2-hydroxymethyl-6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-5-carboxylic acid 4-nitrobenzyl ester

6,7-dihydro-4H-pyrazolo[1,5-a]pyrazine-2,5-dicarboxylic acid 2-ethyl ester 5-(4-nitrobenzyl) ester