Ethanone, 1-[2-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indol-3-yl]-

Base Information

• Chemical Name: Ethanone, 1-[2-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indol-3-yl]-
• CAS No.: 62367-65-1
• Molecular Formula: C₂₁H₂₁NO₂
• Molecular Weight: 319.403
• DSSTox Substance ID: DTXSID80487310
• Mol file: 62367-65-1.mol

Synonyms:62367-65-1;Ethanone, 1-[2-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indol-3-yl]-;DTXSID80487310

Chemical Property of Ethanone, 1-[2-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indol-3-yl]-

Chemical Property:

• XLogP3: 4.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 319.157228913
• Heavy Atom Count: 24
• Complexity: 445

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=C(N(C2=CC=CC=C21)C3CCCCO3)C4=CC=CC=C4

Technology Process of Ethanone, 1-[2-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indol-3-yl]-

There total 1 articles about Ethanone, 1-[2-phenyl-1-(tetrahydro-2H-pyran-2-yl)-1H-indol-3-yl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 1-(2-phenyl-1-tetrahydropyran-2-yl-indol-3-yl)-ethanone (62367-65-1)

Guidance literature:

Phenylacetylindol, N,N-Dimethylformamid, 2-Chlor-tetrahydropyran;

Reference yield:

1-(2-phenyl-1-tetrahydropyran-2-yl-indol-3-yl)-ethanone (62367-65-1) → 4-morpholin-4-yl-1-(2-phenyl-indol-3-yl)-butane-1,3-dione (62367-83-3)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH

2: TsOH / aq. acetic acid / Heating

With sodium hydride; toluene-4-sulfonic acid; In acetic acid;

Reference yield:

morpholine-4-carboxylic acid methyl ester (6906-13-4) + 1-(2-phenyl-1-tetrahydropyran-2-yl-indol-3-yl)-ethanone (62367-65-1) → 4-morpholin-4-yl-1-(2-phenyl-1-tetrahydropyran-2-yl-indol-3-yl)-butane-1,3-dione (62367-75-3)

Guidance literature:

With sodium hydride;

Downstream raw materials:

4-morpholin-4-yl-1-(2-phenyl-1-tetrahydropyran-2-yl-indol-3-yl)-butane-1,3-dione

4-morpholin-4-yl-1-(2-phenyl-indol-3-yl)-butane-1,3-dione