[5-(4-Bromophenyl)thiophen-2-yl]acetic acid

Base Information

Chemical Name:[5-(4-Bromophenyl)thiophen-2-yl]acetic acid
CAS No.:62403-67-2
Molecular Formula:C₁₂H₉BrO₂S
Molecular Weight:297.172
Hs Code.:
DSSTox Substance ID:DTXSID90488999
Wikidata:Q82332045

Synonyms:62403-67-2;[5-(4-Bromophenyl)thiophen-2-yl]acetic acid;DTXSID90488999

Suppliers and Price of [5-(4-Bromophenyl)thiophen-2-yl]acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [5-(4-Bromophenyl)thiophen-2-yl]acetic acid

Chemical Property:

XLogP3:3.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:295.95066
Heavy Atom Count:16
Complexity:251

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC(=CC=C1C2=CC=C(S2)CC(=O)O)Br

Technology Process of [5-(4-Bromophenyl)thiophen-2-yl]acetic acid

There total 6 articles about [5-(4-Bromophenyl)thiophen-2-yl]acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62404-41-5
[5-(4-bromo-phenyl)-thiophen-2-yl]-acetonitrile

: 62403-67-2
[5-(4-bromo-phenyl)-thiophen-2-yl]-acetic acid

Guidance literature:: With potassium hydroxide; In ethanol; water; Heating;
DOI:10.1016/j.bmc.2003.08.009

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 62403-67-2
[5-(4-bromo-phenyl)-thiophen-2-yl]-acetic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: AlCl₃ / CS₂ / 2.5 h / 20 °C

2.1: dimethylformamide / 22 h / 5 °C

3.1: H₂SO₄ / methanol / 1 h / Heating

3.2: chloranil / benzene / 2 h / Heating

4.1: POCl₃ / 1,2-dichloro-ethane / 17 h / Heating

5.1: 76 percent / NaOH; Ag₂O / H₂O / 20 - 50 °C

6.1: 83 percent / H₂SO₄ / toluene / 7 h / Heating

7.1: LiAlH₄ / diethyl ether / Heating

8.1: HMPA; thionyl chloride / tetrahydrofuran / 20 °C

9.1: 18-crown-6 / acetonitrile / 20 °C

10.1: KOH / ethanol; H₂O / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; aluminium trichloride; thionyl chloride; 18-crown-6 ether; sulfuric acid; silver(l) oxide; trichlorophosphate; In tetrahydrofuran; methanol; carbon disulfide; diethyl ether; ethanol; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile; 4.1: Vilsmeier reaction;
DOI:10.1016/j.bmc.2003.08.009

Reference yield:

: 40133-22-0
2-(4-bromophenyl)thiophene

: 62403-67-2
[5-(4-bromo-phenyl)-thiophen-2-yl]-acetic acid

Guidance literature:: Multi-step reaction with 7 steps

1: POCl₃ / 1,2-dichloro-ethane / 17 h / Heating

2: 76 percent / NaOH; Ag₂O / H₂O / 20 - 50 °C

3: 83 percent / H₂SO₄ / toluene / 7 h / Heating

4: LiAlH₄ / diethyl ether / Heating

5: HMPA; thionyl chloride / tetrahydrofuran / 20 °C

6: 18-crown-6 / acetonitrile / 20 °C

7: KOH / ethanol; H₂O / Heating

With N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; thionyl chloride; 18-crown-6 ether; sulfuric acid; silver(l) oxide; trichlorophosphate; In tetrahydrofuran; diethyl ether; ethanol; water; 1,2-dichloro-ethane; toluene; acetonitrile; 1: Vilsmeier reaction;
DOI:10.1016/j.bmc.2003.08.009