1,3-Bis(4-methylphenyl)-2-benzofuran

Base Information

• Chemical Name: 1,3-Bis(4-methylphenyl)-2-benzofuran
• CAS No.: 62422-95-1
• Molecular Formula: C22H18O
• Molecular Weight: 298.384
• DSSTox Substance ID: DTXSID60489519
• Wikidata: Q82332877

Synonyms:62422-95-1;1,3-Di-p-tolylisobenzofuran;1,3-Bis(4-methylphenyl)-2-benzofuran;DTXSID60489519

Chemical Property of 1,3-Bis(4-methylphenyl)-2-benzofuran

Chemical Property:

• XLogP3: 6.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 298.135765193
• Heavy Atom Count: 23
• Complexity: 339

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC=C(C=C1)C2=C3C=CC=CC3=C(O2)C4=CC=C(C=C4)C

Technology Process of 1,3-Bis(4-methylphenyl)-2-benzofuran

There total 7 articles about 1,3-Bis(4-methylphenyl)-2-benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

3-methoxy-3H-isobenzofuran-1-one (4122-57-0) + para-methylphenylmagnesium bromide (4294-57-9) → 1,3-di-p-tolylbenzo[c]furan (62422-95-1)

Guidance literature:

In tetrahydrofuran; at 20 ℃;

DOI:10.1055/s-2006-948179

Reference yield: 63.0%

[2-Diethylamino-6-(4-methyl-benzoyl)-cyclohex-3-enyl]-p-tolyl-methanone (74322-72-8) → 1,3-di-p-tolylbenzo[c]furan (62422-95-1)

Guidance literature:

With PPA; at 110 ℃; for 0.166667h;

DOI:10.1055/s-1980-28946

Reference yield:

1,2-phenylenebis(p-tolylmethanone) (42211-60-9) → 1,3-di-p-tolylbenzo[c]furan (62422-95-1)

Guidance literature:

With sodium hydroxide; ethanol; zinc;

DOI:10.1021/ja01862a071

upstream raw materials:

1,2-phenylenebis(p-tolylmethanone)

[2-Diethylamino-6-(4-methyl-benzoyl)-cyclohex-3-enyl]-p-tolyl-methanone

ethanol

3-methoxy-3H-isobenzofuran-1-one

Downstream raw materials:

[2-(2,2-Dichloro-1-p-tolyl-vinyl)-phenyl]-p-tolyl-methanone

1,2-phenylenebis(p-tolylmethanone)

1,3-di(p-tolyl)benzo[c]selenophene

6,11-di-p-tolylbenzo[d]naphtho[2,3-b]thiophene

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