(5S)-5-(2-Methylpropyl)pyrrolidin-2-one

Base Information

Chemical Name:(5S)-5-(2-Methylpropyl)pyrrolidin-2-one
CAS No.:62430-05-1
Molecular Formula:C8H15NO
Molecular Weight:141.21100
Hs Code.:
DSSTox Substance ID:DTXSID60558456
Nikkaji Number:J461.583B
Wikidata:Q82440770
Mol file:62430-05-1.mol

Synonyms:62430-05-1;(5S)-5-(2-Methylpropyl)pyrrolidin-2-one;2-Pyrrolidinone, 5-(2-methylpropyl)-, (S)-;(S)-5-Isobutylpyrrolidin-2-one;SCHEMBL12604536;DTXSID60558456

Suppliers and Price of (5S)-5-(2-Methylpropyl)pyrrolidin-2-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of (5S)-5-(2-Methylpropyl)pyrrolidin-2-one

Chemical Property:

PSA：32.59000
LogP:1.58700
XLogP3:1.4
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:1
Rotatable Bond Count:2
Exact Mass:141.115364102
Heavy Atom Count:10
Complexity:131

Purity/Quality:: NLT 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)CC1CCC(=O)N1
Isomeric SMILES:CC(C)C[C@@H]1CCC(=O)N1

Technology Process of (5S)-5-(2-Methylpropyl)pyrrolidin-2-one

There total 6 articles about (5S)-5-(2-Methylpropyl)pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 920-66-1
1,1,1,3',3',3'-hexafluoro-propanol

: C₉H₁₅NO₃

: C₁₁H₁₇F₆NO₂

: 62430-05-1
(+)-5(S)-(2-Methylpropyl)-2-pyrrolidinone

Guidance literature:: With C₄₇H₄₇ClIrN₃O₅; at 20 ℃; for 12h; enantioselective reaction;
DOI:10.1021/jacs.9b02811

Reference yield: 65.0%

: 139564-38-8
(+)-N-<2-(1-Hydroxy-2(R)-phenylethyl)>-5(S)-(2-methylpropyl)-2-pyrrolidinone

: 62430-05-1
(+)-5(S)-(2-Methylpropyl)-2-pyrrolidinone

Guidance literature:: With ammonia; lithium; In tetrahydrofuran; ethanol; -33 deg C to r.t., 4 h;
DOI:10.1021/jo00032a012

Reference yield:

: 60856-79-3
4-oxo-6-methylheptanoic acid

: 62430-05-1
(+)-5(S)-(2-Methylpropyl)-2-pyrrolidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / toluene / Heating

2: 85 percent / Et₃SiH, TiCl₄ / CH₂Cl₂ / a) -78 deg C, 1.5 h, b) r.t., 12 h

3: 65 percent / Li, liq. NH₃ / ethanol; tetrahydrofuran / -33 deg C to r.t., 4 h

With triethylsilane; ammonia; titanium tetrachloride; lithium; In tetrahydrofuran; ethanol; dichloromethane; toluene;
DOI:10.1021/jo00032a012