2-(4-chlorophenyl)indolizine

Base Information

• Chemical Name: 2-(4-chlorophenyl)indolizine
• CAS No.: 7496-73-3
• Molecular Formula: C14H10ClN
• Molecular Weight: 227.693
• Hs Code.: 2933990090
• Mol file: 7496-73-3.mol

Synonyms:2-(4-CHLORO-PHENYL)-INDOLIZINE;2-(2-FLUORO-BENZOYLAMINO)-3-METHYL-BUTYRIC ACID;

Chemical Property of 2-(4-chlorophenyl)indolizine

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 4.41000
• Density: 1.18g/cm³
• LogP: 4.25970

Purity/Quality:

NLT 98% ^*data from raw suppliers

2-(4-Chlorophenyl)indolizine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(4-Chlorophenyl)indolizine is used as a reagent in the synthesis of 2-Aryl-3-(4-dialkylaminopropoxybenzoyl)indolizines which are useful in the treatment of angina pectoris.

Technology Process of 2-(4-chlorophenyl)indolizine

There total 8 articles about 2-(4-chlorophenyl)indolizine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1-(2-(4-chlorophenyl)-2-oxoethyl)-2-methylpyridinium bromide (82746-43-8) → 2-(4-chlorophenyl)indolizine (7496-73-3)

Guidance literature:

With sodium hydrogencarbonate; In water; for 0.333333h; Heating;

DOI:10.1002/jps.2600710519

Reference yield: 64.0%

1-(2-(4-chlorophenyl)-2-oxoethyl)-2-methylpyridinium bromide (82746-43-8) + N,N-dimethylformamide di-tert-butyl acetal (36805-97-7) → (4-chlorophenyl)(indolizin-3-yl)methanone + 2-(4-chlorophenyl)indolizine (7496-73-3)

Guidance literature:

In N,N-dimethyl-formamide; at 130 ℃; for 0.166667h;

DOI:10.1016/j.tetlet.2006.10.052

Reference yield: 55.0%

p-chlorophenacyl-α-picolinium iodide → 2-(4-chlorophenyl)indolizine (7496-73-3)

Guidance literature:

With sodium hydrogencarbonate; In water; for 0.166667h; Heating;

upstream raw materials:

1-(2-(4-chlorophenyl)-2-oxoethyl)-2-methylpyridinium bromide

N,N-dimethylformamide di-tert-butyl acetal

α-picoline

4-chlorobenzoylmethyl bromide

Downstream raw materials:

2-chloro-4-[2-(4-chlorophenyl)indolizin-3-yl]quinazoline

2,5-bis(4-chlorophenyl)indolizine

2-(4-chlorophenyl)-5-(p-tolyl)indolizine

Refernces

• 1、 Wang, Yumei,Zhang, Ziwu,Deng, Lichan,Lao, Tianfeng,Su, Zhengquan,Yu, Yue,Cao, Hua. "Mechanochemical Synthesis of 1,2-Diketoindolizine Derivatives from Indolizines and Epoxides Using Piezoelectric Materials". supporting information. p. 7171 - 7176. Retrieved 2021/09/14.
• 2、 Amaral, M?nica F.Z.J.,Deliberto, Laila A.,De Souza, Camila R.,Naal, Rose M.Z.G.,Naal, Zeki,Clososki, Giuliano C.. "Synthesis, photophysical, and electrochemical properties of 2,5-diaryl-indolizines". . p. 3249 - 3258. Retrieved 2014/05/06.