1H-Phosphole-2-carboxylic acid, 3,4-dimethyl-1-phenyl-, ethyl ester

Base Information

Chemical Name:1H-Phosphole-2-carboxylic acid, 3,4-dimethyl-1-phenyl-, ethyl ester
CAS No.:62451-16-5
Molecular Formula:C₁₅H₁₇O₂P
Molecular Weight:260.273
Hs Code.:

Synonyms:1-phenyl-2-ethoxycarbonyl-3,4-dimethylphosphole;3,4-dimethyl-1-phenyl-1H-phosphole-2-carboxylic acid ethyl ester;1H-Phosphole-2-carboxylic acid,3,4-dimethyl-1-phenyl-,ethyl ester;

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Chemical Property of 1H-Phosphole-2-carboxylic acid, 3,4-dimethyl-1-phenyl-, ethyl ester

Chemical Property:

PSA：39.89000
LogP:4.01850

Purity/Quality:

Safty Information:

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Technology Process of 1H-Phosphole-2-carboxylic acid, 3,4-dimethyl-1-phenyl-, ethyl ester

There total 7 articles about 1H-Phosphole-2-carboxylic acid, 3,4-dimethyl-1-phenyl-, ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62451-10-9
3,4-dimethyl-1-phenyl-1-thioxo-1H-1λ⁵-phosphole-2-carboxylic acid ethyl ester

: 62451-16-5
1-phenyl-2-ethoxycarbonyl-3,4-dimethylphosphole

Guidance literature:: With tributylphosphine; In chloroform-d1; at 100 ℃; for 1h;
DOI:10.1016/0040-4020(76)87022-6

Reference yield:

: 74395-12-3
1-phenyl-3,4-dimethylphosphole oxide

: 62451-16-5
1-phenyl-2-ethoxycarbonyl-3,4-dimethylphosphole

Guidance literature:: Multi-step reaction with 5 steps

1: pyridinium tribromide / CH₂Cl₂ / 0.5 h / Ambient temperature

2: P₄S₁₀ / toluene / 0.17 h / Heating

3: 85 percent / KOH / methanol; CH₂Cl₂ / Ambient temperature

4: 90 percent / P(CH₂CH₂CN)3 / toluene / 4 h / Heating

5: 1) n-BuLi / multistep reaction; also with CO₂, HC(O)NMe₂, PhCO₂Et, ClSiMe₃

With potassium hydroxide; n-butyllithium; tetraphosphorus decasulfide; tris(2-cyanoethyl)phosphine; pyridinium hydrobromide perbromide; In methanol; dichloromethane; toluene;

Reference yield:

: 146440-98-4
2-Bromo-3,4-dimethyl-1-phenyl-phosphole 1-sulfide

: 62451-16-5
1-phenyl-2-ethoxycarbonyl-3,4-dimethylphosphole

Guidance literature:: Multi-step reaction with 2 steps

1: 90 percent / P(CH₂CH₂CN)3 / toluene / 4 h / Heating

2: 1) n-BuLi / multistep reaction; also with CO₂, HC(O)NMe₂, PhCO₂Et, ClSiMe₃

With n-butyllithium; tris(2-cyanoethyl)phosphine; In toluene;