4-chloro-5-Methoxy-2-Methylaniline

Base Information

• Chemical Name: 4-chloro-5-Methoxy-2-Methylaniline
• CAS No.: 62492-42-6
• Molecular Formula: C8H10ClNO
• Molecular Weight: 171.626
• Mol file: 62492-42-6.mol

Synonyms:6-Chlor-3-amino-p-kresol-methylaether;4-chloro-5-methoxy-2-methylbenzenamine;5-Chlor-2-amino-4-methoxy-toluol;Benzenamine,4-chloro-5-methoxy-2-methyl;4-Chlor-5-methoxy-2-methyl-anilin;5-amino-2-chloro-4-methylanisole;4-chloro-5-methoxy-2-methyl-aniline;5-Chlor-2-amino-4-methoxy-1-methyl-benzol;

Chemical Property of 4-chloro-5-Methoxy-2-Methylaniline

Chemical Property:

• PSA: 35.25000
• LogP: 2.82040

Purity/Quality:

99% ^*data from raw suppliers

4-Chloro-5-methoxy-2-methylaniline 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-chloro-5-Methoxy-2-Methylaniline

There total 9 articles about 4-chloro-5-Methoxy-2-Methylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(4-chloro-5-methoxy-2-methylphenyl)-2,2,2-trifluoroacetamide → 4-chloro-5-methoxy-2-methylaniline (62492-42-6)

Guidance literature:

With water; sodium hydroxide; In ethanol; water; at 20 - 80 ℃; for 0.5h;

Reference yield:

5-methoxy-o-toluidine (50868-72-9) → 4-chloro-5-methoxy-2-methylaniline (62492-42-6)

Guidance literature:

Multi-step reaction with 3 steps

1: dichloromethane; water

2: sulfuryl dichloride / chloroform / Cooling with ice

3: sodium hydroxide; water / water; ethanol / 0.5 h / 20 - 80 °C

With sulfuryl dichloride; water; sodium hydroxide; In ethanol; dichloromethane; chloroform; water;

Reference yield:

2,2,2-trifluoro-N-(5-methoxy-2-methylphenyl)acetamide (68545-88-0) → 4-chloro-5-methoxy-2-methylaniline (62492-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuryl dichloride / chloroform / Cooling with ice

2: sodium hydroxide; water / water; ethanol / 0.5 h / 20 - 80 °C

With sulfuryl dichloride; water; sodium hydroxide; In ethanol; chloroform; water;

upstream raw materials:

4-Methyl-3-nitroanisole

1-chloro-2-methoxy-5-methyl-4-nitrobenzene

2-methoxy-4-nitro-5-methyl aniline

N-(2-methoxy-5-methylphenyl)acetamide

Downstream raw materials:

acetic acid-(4-chloro-5-methoxy-2-methyl-anilide)

2-chloro-5-fluoro-4-methylanisole

4-(4-chloro-5-methoxy-2-methylanilino)-8-methoxy-7-[2-(4-morpholinyl)ethoxy]benzo[g]quinoline-3-carbonitrile

Refernces

• 1、 -. "Compounds and methods for doping liquid crystal hosts". . . Retrieved 2008/06/13.