50868-72-9

Basic information

• Product Name: 5-Methoxy-2-methylaniline
• Synonyms: 5-Methoxy-2-Methylaniline, 97% 1GR;5-Methoxy-2-Methylaniline, 97% 5GR;3-AMino-4-Methylanisole[5-Methoxy-2-Methylaniline];LABOTEST-BB LTBB000645;6-METHYL-M-ANISIDINE;5-METHOXY-2-METHYLANILINE;5-methoxy-o-toluidine;2-methyl-5-Methoxyaniline
• CAS NO: 50868-72-9
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.18
• EINECS: 256-816-4
• Product Categories: Amines;Building Blocks;C8;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks;Anilines, Aromatic Amines and Nitro Compounds
• Mol File: 50868-72-9.mol
• Article Data: 11

Chemical Properties

• Melting Point: 43-46 °C(lit.)
• Boiling Point: 253°C(lit.)
• Flash Point: >230 °F
• Appearance: Off-white to pale grey to yellow/Powder
• Density: 1.0630 (rough estimate)
• Vapor Pressure: 0.02mmHg at 25°C
• Refractive Index: 1.5647 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.03±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 5-Methoxy-2-methylaniline(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methoxy-2-methylaniline(50868-72-9)
• EPA Substance Registry System: 5-Methoxy-2-methylaniline(50868-72-9)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• HazardClass: 6.1
• Hazardous Substances Data: 50868-72-9(Hazardous Substances Data)

Usage

Chemical Properties

White to gray to tan crystalline powder

Uses

5-Methoxy-2-methylaniline was used in the preparation of N-(5-methoxy-2-methylphenyl)acetamide.

InChI:InChI=1/C8H11NO/c1-6-3-4-7(10-2)5-8(6)9/h3-5H,9H2,1-2H3

Upstream product

• 17484-36-5 4-Methyl-3-nitroanisole 
• 7732-18-5 water 
• 64-19-7 acetic acid 
• 54788-38-4 2-chloro-4-methoxy-1-methylbenzene 
• 621-02-3 di-p-tolyl carbonate 
• 2042-14-0 4-methyl-5-nitrophenol 
• 56843-30-2 acetic acid-(2-methoxy-5-methyl-4-nitro-anilide) 
• 6962-44-3 N-(2-methoxy-5-methylphenyl)acetamide 
• 217314-35-7 1-(5-iodo-2-methylphenyl)-2,5-dimethyl-1H-pyrrole 
• 83863-33-6 5-iodo-o-toluidine 
• 217314-36-8 1-(5-methoxy-2-methylphenyl)-2,5-dimethyl-1H-pyrrole 
• 134-19-0 2-methoxy-4-nitro-5-methyl aniline 
• 22002-45-5 2-bromo-4-methylanisole 

Downstream Products

• 50868-75-2 5’-methoxy-2’-methylacetanilide 
• 56724-09-5 5-methoxy-2-methylbenzaldehyde 
• 348617-42-5 7-chloro-4-(5-methoxy-2-methylanilino)-6-nitro-3-quinolinecarbonitrile 
• 1067959-38-9 2-isocyanato-4-methoxy-1-methyl-benzene 
• 622369-78-2 7-fluoro-6-methoxy-4-[(5-methoxy-2-methylphenyl)amino]-3-quinolinecarbonitrile 
• 1119225-37-4 (+/-)-[2-(2,6-Diethyl-phenyl)-4-ethyl-5,6,7,8-tetrahydro-quinolin-5-yl]-(5-methoxy-2-methyl-phenyl)-amine 
• 1119225-87-4 (+/-)-[2-(2,6-Diethyl-phenyl)-4-methoxy-5-propyl-5,6,7,8-tetrahydro-quinolin-5-yl]-(5-methoxy-2-methyl-phenyl)-amine 
• 152626-78-3 5-bromo-6-methoxy-1H-indazole 
• 197156-28-8 1,6-Dimethoxy-4-methyl-9,10-dihydro-acridine-9-carboxylic acid 2,3,6-trifluoro-phenyl ester 
• 197156-27-7 1,6-Dimethoxy-4-methyl-acridine-9-carboxylic acid 2,3,6-trifluoro-phenyl ester 
• 197156-25-5 5-methoxy-2-methylphenyl-3'-methoxyphenylamine 
• 226951-21-9 4-(5-hydroxy-2-methyl-phenyl)-5-methoxy-2-methyl-2,4-dihydro-[1,2,4]triazol-3-one 

Relevant articles and documents

A reassessment of mycophenolic acid as a lead compound for the development of inhibitors of chikungunya virus replication

Mycophenolic acid (MPA) has been previously reported as an inhibitor of the chikugunya virus (CHIKV) with an EC50 value of 0.2 μM. We used MPA as a lead compound designing and synthesizing a series of isatins and benzolactones in a typical medicinal chemistry program. The synthesis and testing of 19 derivatives produced compounds with no desired activity which prompted us to retest the lead compound, MPA. We can reveal that MPA shows no anti-CHIKV activity and therefore needs to be reassessed as a lead compound for this target.

IMIDAZOLIDINEDIONE DERIVATIVES

The invention provides a compound of formula (Ia), and pharmaceutically acceptable salts thereof. The invention also provides use of the compounds or salts as modulators of Kv3.1 and/or Kv3.2, and in the treatment of diseases or disorders where a modulator of Kv3.1 and/or Kv3.2 is required, such as depression and mood disorders, hearing disorders, schizopherenea, substance abuse disorders, sleep disorders or epilepsy.

Deactivation of heterogeneous hydrogenation catalysts by alcoholic solvents

Hydrogenations using supported metal catalysts are ubiquitous in organic chemistry; yet often times there is a lack of knowledge of key subtle mechanistic features of these reactions that can spell the difference between success or failure in a given synthetic application. Herein we detail an unexpected deactivation of certain heterogeneous hydrogenation catalysts caused by the typical solvent of choice for such reactions, simple aliphatic alcohols. This phenomenon was found to be general for several classes of substrates using either Raney Ni or supported Pd-catalysts. The characteristics of this phenomenon, including the reversibility of the catalyst deactivation upon exposure to air, are consistent with literature reports of alcohol decomposition on metal surfaces forming adsorbed CO.