(2-Amino-5-chlorophenyl)(3-hydroxyphenyl)methanone

Base Information

• Chemical Name: (2-Amino-5-chlorophenyl)(3-hydroxyphenyl)methanone
• CAS No.: 62492-58-4
• Molecular Formula: C13H10ClNO2
• Molecular Weight: 247.681
• Hs Code.: 2922509090
• DSSTox Substance ID: DTXSID40383485
• Wikidata: Q82175224
• Mol file: 62492-58-4.mol

Synonyms:(2-Amino-5-chlorophenyl)(3-hydroxyphenyl)methanone;62492-58-4;2-Amino-5-chloro-3'-hydroxybenzophenone;(2-amino-5-chlorophenyl)-(3-hydroxyphenyl)methanone;3-(2-amino-5-chlorobenzoyl)phenol;SCHEMBL4851741;DTXSID40383485;QNYBTFDZVVAFOA-UHFFFAOYSA-N;MFCD01314193;AKOS016004711;AB86708;PS-4515;CS-0313948

Chemical Property of (2-Amino-5-chlorophenyl)(3-hydroxyphenyl)methanone

Chemical Property:

• Melting Point: 190 °C
• PSA: 63.32000
• LogP: 3.44000
• Storage Temp.: 2-8°C
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 247.0400063
• Heavy Atom Count: 17
• Complexity: 285

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-5-chloro-3'-hydroxybenzophenone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC(=CC(=C1)O)C(=O)C2=C(C=CC(=C2)Cl)N

Technology Process of (2-Amino-5-chlorophenyl)(3-hydroxyphenyl)methanone

There total 5 articles about (2-Amino-5-chlorophenyl)(3-hydroxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2-Amino-5-chloro-phenyl)-(3-methoxy-phenyl)-methanone (62492-54-0) → 2-amino-5-chloro-3'-hydroxybenzophenone (62492-58-4)

Guidance literature:

With boron tribromide; In dichloromethane;

DOI:10.1002/hlca.19770600134

Reference yield:

6-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one (7033-50-3) → 2-amino-5-chloro-3'-hydroxybenzophenone (62492-58-4)

Guidance literature:

Multi-step reaction with 3 steps

1: (i) Mg, Et₂O, (ii) /BRN= 140708/, benzene

2: aq. HCl / ethanol

3: BBr₃ / CH₂Cl₂

With hydrogenchloride; boron tribromide; In ethanol; dichloromethane;

DOI:10.1002/hlca.19770600134

Reference yield:

2-Acetylamino-5-chlor-3'-methoxy-benzophenon (62492-51-7) → 2-amino-5-chloro-3'-hydroxybenzophenone (62492-58-4)

Guidance literature:

Multi-step reaction with 2 steps

1: aq. HCl / ethanol

2: BBr₃ / CH₂Cl₂

With hydrogenchloride; boron tribromide; In ethanol; dichloromethane;

DOI:10.1002/hlca.19770600134

upstream raw materials:

(2-Amino-5-chloro-phenyl)-(3-methoxy-phenyl)-methanone

6-chloro-2-methyl-4H-benzo[d][1,3]oxazin-4-one

2-Acetylamino-5-chlor-3'-methoxy-benzophenon

5-chloroanthranilic acid

Downstream raw materials:

6-chloro-4-(3-hydroxyphenyl)-3-(3-methyl-isoxazol-5-yl)-1H-quinolin-2-one

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