N-[4-Chloro-2-(3-methoxybenzoyl)phenyl]acetamide

Base Information

Chemical Name:N-[4-Chloro-2-(3-methoxybenzoyl)phenyl]acetamide
CAS No.:62492-51-7
Molecular Formula:C₁₆H₁₄ClNO₃
Molecular Weight:303.745
Hs Code.:
DSSTox Substance ID:DTXSID00489553
Wikidata:Q82332926

Synonyms:N-[4-Chloro-2-(3-methoxybenzoyl)phenyl]acetamide;62492-51-7;DTXSID00489553

Suppliers and Price of N-[4-Chloro-2-(3-methoxybenzoyl)phenyl]acetamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-Chloro-2-(3-methoxybenzoyl)phenyl]acetamide

Chemical Property:

XLogP3:3.6
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:4
Exact Mass:303.0662210
Heavy Atom Count:21
Complexity:388

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(=O)NC1=C(C=C(C=C1)Cl)C(=O)C2=CC(=CC=C2)OC

Technology Process of N-[4-Chloro-2-(3-methoxybenzoyl)phenyl]acetamide

There total 5 articles about N-[4-Chloro-2-(3-methoxybenzoyl)phenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 62492-54-0
(2-Amino-5-chloro-phenyl)-(3-methoxy-phenyl)-methanone

: 75-36-5
acetyl chloride

: 62492-51-7
2-Acetylamino-5-chlor-3'-methoxy-benzophenon

Guidance literature:: With pyridine; dmap; In dichloromethane; at 25 ℃; for 16h;
DOI:10.1021/jm200312v

Reference yield:

: 635-21-2
5-chloroanthranilic acid

: 62492-51-7
2-Acetylamino-5-chlor-3'-methoxy-benzophenon

Guidance literature:: Multi-step reaction with 2 steps

1: Heating

2: (i) Mg, Et₂O, (ii) /BRN= 140708/, benzene

DOI:10.1002/hlca.19770600134

Reference yield:

: 2398-37-0
3-methoxyphenyl bromide

: 62492-51-7
2-Acetylamino-5-chlor-3'-methoxy-benzophenon

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / diethyl ether; hexane / 2 h / -78 - 0 °C

1.2: 2 h / 0 °C

2.1: pyridine; dmap / dichloromethane / 16 h / 25 °C

With pyridine; dmap; n-butyllithium; In diethyl ether; hexane; dichloromethane;
DOI:10.1021/jm200312v