Dimethyl 2-(benzyloxy)malonate

Base Information

Chemical Name:Dimethyl 2-(benzyloxy)malonate
CAS No.:62527-77-9
Molecular Formula:C12H14O5
Molecular Weight:238.24
Hs Code.:
European Community (EC) Number:962-527-0
DSSTox Substance ID:DTXSID90565416
Nikkaji Number:J3.349.971J
Wikidata:Q82450501

Synonyms:62527-77-9;1,3-DIMETHYL 2-(BENZYLOXY)PROPANEDIOATE;Dimethyl 2-(benzyloxy)malonate;dimethyl 2-phenylmethoxypropanedioate;SCHEMBL1232306;Dimethyl (benzyloxy)propanedioate;DTXSID90565416;HZSPSPQZRIPFCH-UHFFFAOYSA-N;EN300-257583

Suppliers and Price of Dimethyl 2-(benzyloxy)malonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of Dimethyl 2-(benzyloxy)malonate

Chemical Property:

XLogP3:1.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:238.08412354
Heavy Atom Count:17
Complexity:242

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C(C(=O)OC)OCC1=CC=CC=C1

Technology Process of Dimethyl 2-(benzyloxy)malonate

There total 7 articles about Dimethyl 2-(benzyloxy)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.18%

: 6773-29-1
dimethyl diazomalonate

: 100-51-6,185532-71-2
benzyl alcohol

: 62527-77-9
dimethyl 2-(benzyloxy)malonate

Guidance literature:: With rhodium(II) acetate; In dichloromethane; at 0 - 22 ℃; for 16h; Inert atmosphere;

Reference yield: 59.0%

: 31600-43-8
methyl 2-(benzyloxy)acetate

: 79-22-1
methyl chloroformate

: 62527-77-9
dimethyl 2-(benzyloxy)malonate

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -78 ℃;
DOI:10.1016/S0957-4166(01)00040-4

Reference yield:

: 108-59-8
malonic acid dimethyl ester

: 62527-77-9
dimethyl 2-(benzyloxy)malonate

Guidance literature:: Multi-step reaction with 2 steps

1: p-carboxybenzenesulfonyl azide; triethylamine / acetonitrile / 18 h / 0 - 20 °C / Inert atmosphere

2: rhodium(II) acetate / dichloromethane / 16 h / 20 °C

With rhodium(II) acetate; p-carboxybenzenesulfonyl azide; triethylamine; In dichloromethane; acetonitrile;
DOI:10.1016/j.tetlet.2014.06.024