2-Chloro-5-(dimethylamino)benzenesulfonyl chloride

Base Information

• Chemical Name: 2-Chloro-5-(dimethylamino)benzenesulfonyl chloride
• CAS No.: 62533-40-8
• Molecular Formula: C₈H₉Cl₂NO₂S
• Molecular Weight: 254.137
• DSSTox Substance ID: DTXSID701228676
• Mol file: 62533-40-8.mol

Synonyms:DTXSID701228676;2-Chloro-5-(dimethylamino)benzenesulfonyl chloride;62533-40-8

Chemical Property of 2-Chloro-5-(dimethylamino)benzenesulfonyl chloride

Chemical Property:

• XLogP3: 2.7
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 252.9731051
• Heavy Atom Count: 14
• Complexity: 286

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN(C)C1=CC(=C(C=C1)Cl)S(=O)(=O)Cl

Technology Process of 2-Chloro-5-(dimethylamino)benzenesulfonyl chloride

There total 1 articles about 2-Chloro-5-(dimethylamino)benzenesulfonyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-chloro-N,N-dimethylaniline (698-69-1) → 2-Chloro-5-dimethylamino-benzenesulfonyl chloride (62533-40-8)

Guidance literature:

With chlorosulfonic acid;

DOI:10.1021/jo00437a030

Reference yield:

2-Chloro-5-dimethylamino-benzenesulfonyl chloride (62533-40-8) → 2-Chloro-5-dimethylamino-benzenesulfonamide (62533-43-1)

Guidance literature:

With ammonium hydroxide;

DOI:10.1021/jo00437a030

Reference yield:

2-Chloro-5-dimethylamino-benzenesulfonyl chloride (62533-40-8) → 2-Chloro-5-dimethylamino-N-phenyl-benzenesulfonamide (62533-42-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaN₃ / acetone; H₂O

2: benzene / 48 h / 130 °C

With sodium azide; In water; acetone; benzene;

DOI:10.1021/jo00437a030

upstream raw materials:

4-chloro-N,N-dimethylaniline

Downstream raw materials:

2-Chloro-5-dimethylamino-benzenesulfonamide

2-Chloro-5-dimethylamino-benzenesulfonyl azide

2-Chloro-5-dimethylamino-N-phenyl-benzenesulfonamide