1H-Pyrazole-5-carboxylic acid, 1-[(4-methoxyphenyl)methyl]-3-[[[1-[(4-methoxyphenyl)methyl]-3-nitro-1H -pyrazol-5-yl]carbonyl]amino]-, methyl ester

Base Information

Chemical Name:1H-Pyrazole-5-carboxylic acid, 1-[(4-methoxyphenyl)methyl]-3-[[[1-[(4-methoxyphenyl)methyl]-3-nitro-1H -pyrazol-5-yl]carbonyl]amino]-, methyl ester
CAS No.:625386-13-2
Molecular Formula:C25H24N6O7
Molecular Weight:520.49400
Hs Code.:

1H-Pyrazole-5-carboxylic acid,
1-[(4-methoxyphenyl)methyl]-3-[[[1-[(4-methoxyphenyl)methyl]-3-nitro-1H
-pyrazol-5-yl]carbonyl]amino]-, methyl ester

Synonyms:2-(4-Methoxy-benzyl)-5-{[2-(4-methoxy-benzyl)-5-nitro-2H-pyrazole-3-carbonyl]-amino}-2H-pyrazole-3-carboxylic acid methyl ester;

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Chemical Property of 1H-Pyrazole-5-carboxylic acid, 1-[(4-methoxyphenyl)methyl]-3-[[[1-[(4-methoxyphenyl)methyl]-3-nitro-1H -pyrazol-5-yl]carbonyl]amino]-, methyl ester

Chemical Property:

Melting Point:69 °C
Boiling Point:692.6±55.0 °C(Predicted)
PSA：155.32000
Density:1.39±0.1 g/cm3(Predicted)
LogP:3.73670

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1H-Pyrazole-5-carboxylic acid, 1-[(4-methoxyphenyl)methyl]-3-[[[1-[(4-methoxyphenyl)methyl]-3-nitro-1H -pyrazol-5-yl]carbonyl]amino]-, methyl ester

There total 4 articles about 1H-Pyrazole-5-carboxylic acid, 1-[(4-methoxyphenyl)methyl]-3-[[[1-[(4-methoxyphenyl)methyl]-3-nitro-1H -pyrazol-5-yl]carbonyl]amino]-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 625386-12-1
5-amino-2-(p-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

: 625386-11-0
2-(4-methoxybenzyl)-5-nitro-2H-pyrazole-3-carboxylic acid

: 625386-13-2
2-(4-methoxybenzyl)-5-{[2-(4-methoxybenzyl)-5-nitro-2H-pyrazole-3-carbonyl]amino}-2H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: With 2-chloro-1-methyl-pyridinium iodide; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 72h;
DOI:10.1055/s-2003-41031

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 625386-13-2
2-(4-methoxybenzyl)-5-{[2-(4-methoxybenzyl)-5-nitro-2H-pyrazole-3-carbonyl]amino}-2H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / K₂CO₃ / dimethylformamide / 18 h / 50 °C

2: 75 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran

3: 88 percent / i-Pr₂NEt; 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 72 h / 20 °C

With 2-chloro-1-methyl-pyridinium iodide; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2003-41031

Reference yield:

: 625386-10-9
2-(4-methoxybenzyl)-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester

: 625386-13-2
2-(4-methoxybenzyl)-5-{[2-(4-methoxybenzyl)-5-nitro-2H-pyrazole-3-carbonyl]amino}-2H-pyrazole-3-carboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 75 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran

2: 88 percent / i-Pr₂NEt; 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 72 h / 20 °C

With 2-chloro-1-methyl-pyridinium iodide; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1055/s-2003-41031