1H-Pyrazole-5-carboxamide, N-[5-[(butylamino)carbonyl]-1-[(4-methoxyphenyl)methyl]-1H-pyrazol-3-yl ]-1-[(4-methoxyphenyl)methyl]-3-[(1-oxohexyl)amino]-

Base Information

Chemical Name:1H-Pyrazole-5-carboxamide, N-[5-[(butylamino)carbonyl]-1-[(4-methoxyphenyl)methyl]-1H-pyrazol-3-yl ]-1-[(4-methoxyphenyl)methyl]-3-[(1-oxohexyl)amino]-
CAS No.:625386-25-6
Molecular Formula:C₃₄H₄₃N₇O₅
Molecular Weight:629.759
Hs Code.:

1H-Pyrazole-5-carboxamide,
N-[5-[(butylamino)carbonyl]-1-[(4-methoxyphenyl)methyl]-1H-pyrazol-3-yl
]-1-[(4-methoxyphenyl)methyl]-3-[(1-oxohexyl)amino]-

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Chemical Property of 1H-Pyrazole-5-carboxamide, N-[5-[(butylamino)carbonyl]-1-[(4-methoxyphenyl)methyl]-1H-pyrazol-3-yl ]-1-[(4-methoxyphenyl)methyl]-3-[(1-oxohexyl)amino]-

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MSDS Files:: SDS file from LookChem

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Technology Process of 1H-Pyrazole-5-carboxamide, N-[5-[(butylamino)carbonyl]-1-[(4-methoxyphenyl)methyl]-1H-pyrazol-3-yl ]-1-[(4-methoxyphenyl)methyl]-3-[(1-oxohexyl)amino]-

There total 7 articles about 1H-Pyrazole-5-carboxamide, N-[5-[(butylamino)carbonyl]-1-[(4-methoxyphenyl)methyl]-1H-pyrazol-3-yl ]-1-[(4-methoxyphenyl)methyl]-3-[(1-oxohexyl)amino]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 109-73-9,85404-21-3
N-butylamine

: 625386-24-5
5-{[5-hexanoylamino-2-(4-methoxybenzyl)-2H-pyrazole-3-carbonyl]amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid methyl ester

: 625386-25-6
5-{[5-hexanoylamino-2-(4-methoxybenzyl)-2H-pyrazole-3-carbonyl]amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid butylamide

Guidance literature:: In methanol; for 5h; Heating;
DOI:10.1055/s-2003-41031

Reference yield:

: 2746-25-0
p-Methoxybenzyl bromide

: 625386-25-6
5-{[5-hexanoylamino-2-(4-methoxybenzyl)-2H-pyrazole-3-carbonyl]amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid butylamide

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / K₂CO₃ / dimethylformamide / 18 h / 50 °C

2: 75 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran

3: 88 percent / i-Pr₂NEt; 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 72 h / 20 °C

4: 58 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran

5: 98 percent / i-Pr₂NEt / tetrahydrofuran / 16 h / 20 °C

6: 98 percent / methanol / 5 h / Heating

With 2-chloro-1-methyl-pyridinium iodide; hydrogen; potassium carbonate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1055/s-2003-41031

Reference yield:

: 625386-10-9
2-(4-methoxybenzyl)-5-nitro-2H-pyrazole-3-carboxylic acid methyl ester

: 625386-25-6
5-{[5-hexanoylamino-2-(4-methoxybenzyl)-2H-pyrazole-3-carbonyl]amino}-2-(4-methoxybenzyl)-2H-pyrazole-3-carboxylic acid butylamide

Guidance literature:: Multi-step reaction with 5 steps

1: 75 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran

2: 88 percent / i-Pr₂NEt; 2-chloro-1-methylpyridinium iodide / CH₂Cl₂ / 72 h / 20 °C

3: 58 percent / H₂ / 10 percent Pd/C / methanol; tetrahydrofuran

4: 98 percent / i-Pr₂NEt / tetrahydrofuran / 16 h / 20 °C

5: 98 percent / methanol / 5 h / Heating

With 2-chloro-1-methyl-pyridinium iodide; hydrogen; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1055/s-2003-41031