1-tert-butyl 2-methyl (2S,4R)-4-hydroxypiperidine-1,2-dicarboxylate

Base Information Edit

Chemical Name:1-tert-butyl 2-methyl (2S,4R)-4-hydroxypiperidine-1,2-dicarboxylate
CAS No.:254882-06-9
Molecular Formula:C12H21 N O5
Molecular Weight:259.302
Hs Code.:2933399990
European Community (EC) Number:640-482-5,806-069-0
ChEMBL ID:CHEMBL4963714
DSSTox Substance ID:DTXSID70461684
Nikkaji Number:J1.671.305H
Wikidata:Q76416931
Mol file:254882-06-9.mol

Synonyms:181269-87-4;254882-06-9;1-tert-butyl 2-methyl (2S,4R)-4-hydroxypiperidine-1,2-dicarboxylate;(2S,4R)-1-tert-Butyl 2-methyl 4-hydroxypiperidine-1,2-dicarboxylate;(2S,4R)-N-BOC-4-Hydroxypiperidine-2-carboxylic acid methyl ester;(2S,4R)-N-BOC-4-HYDROXYPIPERIDINE-2-CARBOXYLIC ACID METHYL ESTER, 98% E.E., 95;1-(tert-Butyl) 2-methyl (2S,4R)-4-hydroxypiperidine-1,2-dicarboxylate;MFCD02259709;1-O-tert-butyl 2-O-methyl (2S,4R)-4-hydroxypiperidine-1,2-dicarboxylate;CIS-4-HYDROXY-PIPERIDINE-1,2-DICARBOXYLIC ACID1-TERT-BUTYL ESTER 2-METHYL ESTER;1-(tert-Butyl) 2-methyl (2S,4R)-4-hydroxy-tetrahydro-1,2(2H)-pyridinedicarboxylate;1-TERT-BUTYL 2-METHYL CIS-4-HYDROXYPIPERIDINE-1,2-DICARBOXYLATE;CIS-4-HYDROXY-PIPERIDINE-1,2-DICARBOXYLIC ACID 1-TERT-BUTYL ESTER 2-METHYL ESTER;RNMVWSAJMIKMDY-BDAKNGLRSA-N;SCHEMBL585389;CHEMBL4963714;DTXSID70461684;Methyl cis-1-boc-4-hydroxypiperidine-2-carboxylate;1,2-Piperidinedicarboxylic acid, 4-hydroxy-, 1-(1,1-dimethylethyl) 2-methyl ester, (2R,4S)-rel-;1-tert-butyl 2-methyl (2S,4R)-rel-4-hydroxypiperidine-1,2-dicarboxylate;AKOS005256940;AKOS015892403;EE-0204;(2S,4R)-4-hydroxy-piperidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-methyl ester;CS-0052387;CS-0356789;P16501;P21135;EN300-7389157;EN300-19814087;Methyl (2S,4R)-1-boc-4-hydroxypiperidine-2-carboxylate;cis-1-tert-Butyl 2-methyl 4-hydroxypiperidine-1,2-dicarboxylate;rac-1-tert-butyl 2-methyl (2R,4S)-4-hydroxypiperidine-1,2-dicarboxylate;(2S,4R)-N-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylic acid methyl ester;(2S,4R)-N-Boc-4-hydroxypiperidine-2-carboxylic acid methyl ester, AldrichCPR;1-(tert-Butyl) 2-methyl (2S,4R)-4-hydroxytetrahydro-1,2(2H)-pyridinedicarboxylate;CIS-4-HYDRoxypipERIDINE-1,2-DICARBOXYLIC ACID 1-tert-butyl 2-METHYL ESTER

Suppliers and Price of 1-tert-butyl 2-methyl (2S,4R)-4-hydroxypiperidine-1,2-dicarboxylate

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 11 raw suppliers

Chemical Property of 1-tert-butyl 2-methyl (2S,4R)-4-hydroxypiperidine-1,2-dicarboxylate Edit

Chemical Property:

Vapor Pressure:0mmHg at 25°C
Refractive Index:1.4596 (estimate)
Boiling Point:352.1°Cat760mmHg
PKA:14.39±0.40(Predicted)
Flash Point:166.8°C
PSA：76.07000
Density:1.182g/cm³
LogP:0.85770
XLogP3:0.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:259.14197277
Heavy Atom Count:18
Complexity:323

Purity/Quality:: 95-99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: S24/25:Avoid contact with skin and eyes.;

MSDS Files:

Useful:

Canonical SMILES:CC(C)(C)OC(=O)N1CCC(CC1C(=O)OC)O
Isomeric SMILES:CC(C)(C)OC(=O)N1CC[C@H](C[C@H]1C(=O)OC)O

Technology Process of 1-tert-butyl 2-methyl (2S,4R)-4-hydroxypiperidine-1,2-dicarboxylate

There total 10 articles about 1-tert-butyl 2-methyl (2S,4R)-4-hydroxypiperidine-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1799811-83-8
1-(tert-butyl)-2-methyl-(S)-4-oxopiperidine-1,2-dicarboxylate

: 254882-06-9,181269-87-4
(2S,4R)-methyl 1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate

Guidance literature:: With L-Selectride; In tetrahydrofuran; at -78 ℃; for 1h;

Reference yield: 83.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 403503-37-7,1357348-22-1
(2S,4R)-1-benzyl 2-methyl 4-hydroxypiperidine-1,2-dicarboxylate

: 254882-06-9,181269-87-4
(2S,4R)-methyl 1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate

Guidance literature:: With hydrogen; palladium on activated charcoal;
DOI:10.1016/j.tet.2003.10.116

Reference yield: 65.0%

: (1S,5R)-2-[(R)-2-phenylethyl]-6-oxa-2-azabicyclo[3.2.1]octan-7-one

: 24424-99-5
di-tert-butyl dicarbonate

: 254882-06-9,181269-87-4
(2S,4R)-methyl 1-(tert-butoxycarbonyl)-4-hydroxypiperidine-2-carboxylate

Guidance literature:: (1S,5R)-2-[(R)-2-phenylethyl]-6-oxa-2-azabicyclo[3.2.1]octan-7-one; With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In 1,4-dioxane; methanol; at 20 ℃;

With triethylamine; In dichloromethane; at 20 ℃; for 0.25h;

di-tert-butyl dicarbonate; In dichloromethane; at 20 ℃;