Isopromethazine hydrochloride

Base Information

Chemical Name:Isopromethazine hydrochloride
CAS No.:5568-90-1
Molecular Formula:C17H21ClN2S
Molecular Weight:320.88
Hs Code.:2934300000
UNII:SNR56923ZU
DSSTox Substance ID:DTXSID10971030
Wikidata:Q27289303
Mol file:5568-90-1.mol

Synonyms:Isopromethazine hydrochloride;5568-90-1;Iso Promethazine Hydrochloride;Diprazin hydrochloride;Isopromethazine HCl;N,N-dimethyl-2-phenothiazin-10-ylpropan-1-amine;hydrochloride;UNII-SNR56923ZU;SNR56923ZU;N-(beta-Dimethylamino-alpha-methylethyl)phenothiazine hydrochloride;Phenothiazine, 10-(2-(dimethylamino)-1-methylethyl)-, hydrochloride;10H-Phenothiazine-10-ethanamine, N,N,.beta.-trimethyl-, monohydrochloride;10H-Phenothiazine-10-ethanamine, N,N,beta-trimethyl-, monohydrochloride;(2RS)-N,N-Dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine Hydrochloride (Isopromethazine Hydrochloride);Phenothiazine, 10-[2-(dimethylamino)-1-methylethyl]-, monohydrochloride;PHENOTHIAZINE, 10-(2-(DIMETHYLAMINO)-1-METHYLETHYL)-, MONOHYDROCHLORIDE;SCHEMBL3712233;DTXSID10971030;10-[2-(Dimethylamino)-1-methylethyl]phenothiazine Monohydrochloride;AKOS030242437;ISOPROMETHAZINE HYDROCHLORIDE [MI];LS-105474;FT-0670482;ISOPROMETHAZINE HYDROCHLORIDE [WHO-DD];Q27289303;N,N-Dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine hydrochloride;10H-PHENOTHIAZINE-10-ETHANAMINE, N,N,.BETA.-TRIMETHYL-, HYDROCHLORIDE (1:1);N,N-Dimethyl-2-(10H-phenothiazin-10-yl)propan-1-amine--hydrogen chloride (1/1)

Suppliers and Price of Isopromethazine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
IsoPromethazineHydrochloride
1g
$ 1695.00

TRC
IsoPromethazineHydrochloride
100mg
$ 215.00

American Custom Chemicals Corporation
ISOPROMETHAZINE HYDROCHLORIDE 95.00%
2.5G
$ 1815.00

American Custom Chemicals Corporation
ISOPROMETHAZINE HYDROCHLORIDE 95.00%
250MG
$ 721.88

Total 11 raw suppliers

Chemical Property of Isopromethazine hydrochloride

Chemical Property:

Vapor Pressure:1.02E-06mmHg at 25°C
Melting Point:204 °C
Boiling Point:403.4°Cat760mmHg
Flash Point:197.8°C
PSA：31.78000
Density:g/cm³
LogP:5.10640
Storage Temp.:Hygroscopic, Refrigerator, Under inert atmosphere
Solubility.:Chloroform (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:3
Exact Mass:320.1113975
Heavy Atom Count:21
Complexity:298

Purity/Quality:

99%, ^*data from raw suppliers

IsoPromethazineHydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(CN(C)C)N1C2=CC=CC=C2SC3=CC=CC=C31.Cl
Uses Promethazine (P757000) impurity. Iso Promethazine Hydrochloride (Promethazine EP Impurity B) is a Promethazine (P757000) impurity.

Technology Process of Isopromethazine hydrochloride

There total 3 articles about Isopromethazine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: 86382-43-6
N,N,β-trimethyl-10H-phenothiazine-10-α-oxoethanamine

: 5568-90-1
diprazin

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; for 2h;
DOI:10.1002/jps.2600720525

Reference yield:

: 92-84-2
10H-phenothiazine

: 5568-90-1
diprazin

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-butyllithium / 1.) ether, hexane, -30 - -20 deg C, 30 min, 2.) 1 h

2: 72 percent / lithium aluminum hydride / tetrahydrofuran / 2 h

With lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran;
DOI:10.1002/jps.2600720525

Reference yield:

: 10397-68-9,152786-29-3
2-chloro-N,N-dimethyl-propionamide

: 5568-90-1
diprazin

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) n-butyllithium / 1.) ether, hexane, -30 - -20 deg C, 30 min, 2.) 1 h

2: 72 percent / lithium aluminum hydride / tetrahydrofuran / 2 h

With lithium aluminium tetrahydride; n-butyllithium; In tetrahydrofuran;
DOI:10.1002/jps.2600720525