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High purity Phenothiazine 99.5% TOP1 supplier in China
Cas No: 92-84-2
USD $ 1.0-1.0 / Kilogram 1 Kilogram 100 Kilogram/Week Hangzhou Dayangchem Co., Ltd. Contact Supplier
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USD $ 7.0-15.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
Phenothiazine PTZ CAS 92-84-2
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USD $ 1.0-1.0 / Metric Ton 1 Metric Ton 1000 Metric Ton/Day Scale Chemical Corporation Contact Supplier
Phenothiazine (500 mg)
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USD $ 1.0-2.0 / Metric Ton 5 Metric Ton 2500 Metric Ton/Year Henan Sinotech Import&Export Corporation Contact Supplier
92-84-2 Agrazine
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USD $ 8900.0-8900.0 / Gram 1 Gram 200 Gram/Day Henan Tianfu Chemical Co., Ltd. Contact Supplier
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USD $ 1000.0-1500.0 / Kilogram 1 Kilogram 100 Metric Ton/Month Crovell Biotech (Hebei) Co., Ltd. Contact Supplier

92-84-2 Usage

Uses

  • Phenothiazine is a relatively widely used anthelmintic reagent with excellent efficacy in treating the Haemonchus contortus of cattle, horse and sheep, nodular worm, Bunostomum and Plasmodium chabaudi.
  • Phenothiazine is the intermediates of fine chemicals such as dyes and drugs with itself being a auxiliary material for synthetic material (the anti-polymerization reagent for production of vinylon), fruit pesticides and veterinary anthelmintic.
  • It is mainly used as the polymerization inhibitor for acrylic acid, acrylic esters, and methacrylic aicd as well as ester monomer.

Reactivity Profile

Phenothiazine is slowly decomposed by sunlight. . Organosulfides are incompatible with acids, diazo and azo compounds, halocarbons, isocyanates, aldehydes, alkali metals, nitrides, hydrides, and other strong reducing agents. Reactions with these materials generate heat and in many cases hydrogen gas. Many of these compounds may liberate hydrogen sulfide upon decomposition or reaction with an acid.

Chemical Properties

yellow or pale green powder

Fire Hazard

Flash point data for Phenothiazine are not available, but Phenothiazine is probably combustible.

Uses

A rigid, tricyclic thiazine useful as an electron donor.

Uses

A key component of antipsychotic and antihistaminic drugs.

Uses

Insecticide; manufacture of pharmaceuticals.

Brand name

Nemazine (Parke-Davis).

Purification Methods

Crystallise it from *benzene, toluene, hexane or Me2CO (charcoal) after boiling for 10minutes under reflux. Filter the crystals off and dry them in an oven at 100o, then in a vacuum desiccator over paraffin chips. Also recrystallise it twice from water and dry it in an oven at 100o for 8-10hours. It sublimes at 130o/1mm and has UV with at 253nm in heptane. [Beilstein

Air & Water Reactions

Insoluble in water.

Chemical Properties

It is clean gray-green powder with the melting point of 185.5 ℃, boiling point of 371 ℃, 290 ℃ (5.33kPa). It is insoluble in petroleum ether, chloroform and water, and soluble in ether and hot acetic acid. It will be oxidized upon exposure to light in the air.

description

Phenothiazine is a class of agents exhibiting antiemetic, antipsychotic, antihistaminic, and anticholinergic activities. Phenothiazines antagonize the dopamine D2-receptor in the chemoreceptor trigger zone (CTZ) of the brain, potentially preventing chemotherapy-induced emesis. In addition, these agents have peripherally or centrally antagonistic activity against alpha adrenergic, serotonergic, histaminic, and muscarinic receptors.
Phenothiazines are used to treat serious mental and emotional disorders, including schizophrenia and other psychotic disorders. Some are used also to control agitation in certain patients, severe nausea and vomiting, severe hiccups, and moderate to severe pain in some hospitalized patients. Chlorpromazine is used also in the treatment of certain types of porphyria, and with other medicines in the treatment of tetanus. Phenothiazines may also be used for other conditions as determined by your doctor.

General Description

Light green to steel-blue powder. Acquires a greenish-brown tint under exposure to sunlight.

Synthesis

22 g of diphenylamine, 8.2 g of sulfur, and 3.2 gms. of anhydrous aluminum chloride are melted together. The reaction sets 140-150° C with the rapid evolution of hydrogen sulfide; by lowerg the temperature, a few degrees the reaction can be slackened. Wen the reaction has moderated, the temperature is raised to 160° C for a time. The melt, when cool, is ground up and extracted, first with water and then with dilute alcohol. The residue consists of almost pure phenothiazine. It can be recrystallised from alcohol. Yield 93%, yellowish leaflets; m.p. 180° C.
Preparation of phenothiazine
Systematic organic chemistry, by W. M. Cumming, 325-326, 1937.

Definition

ChEBI: The 10H-tautomer of phenothiazine.

Uses

Employed in the preparation of carbazoles and piperazines,1 and charge-transfer semiconducting complexes.2

side effects

For more than a decade, phenothiazine drugs have been used to treat a variety of disorders and have proved particularly effective in the treatment of schizophrenia. Clinical experience indicates that initial extremely high dosages are necessary to effect improvement of patients with schizophrenic illnesses.
During 1964, several sequelae have been reported following prolonged high dosage of these drugs. These recent reports refer to side effects which are apparently permanent, in contrast to earlier communications of transient deleterious effects. For example, it has been known for several years that extrapyramidal disorders occur frequently in patients taking phenothiazines; however, a reduction in dosage or cessation of medication appeared to produce a return to the normal state.
Phenothiazines may cause unwanted, unattractive, and uncontrolled face or body movements that may not go away when you stop taking the medicine. They may also cause other serious unwanted effects. You and your doctor should talk about the good this medicine will do as well as the risks of using it. Also, your doctor should look for early signs of these effects at regular visits. Your doctor may be able to stop or decrease some unwanted effects, if they do occur, by changing your dose or by making other changes in your treatment.
These medicines are available only with your doctor's prescription.
Levoprome(R) (methotrimeprazine) is no longer available in the United States. At the end of May 1998, Immunex Corporation stopped marketing it.
Once a medicine has been approved for marketing for a certain use, experience may show that it also is useful for other medical problems. Although these uses are not included in product labeling, phenothiazines are used in certain patients with the following medical conditions:
  • Chronic neurogenic pain (certain continuing pain conditions)
  • Huntington's chorea (hereditary movement disorder)
  • Migraine headaches

92-84-2 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
USP (1525707)  Phenothiazine  United States Pharmacopeia (USP) Reference Standard 92-84-2 1525707-500MG 4,662.45CNY Detail
Vetec (V900773)  Phenothiazine  Vetec reagent grade, 98% 92-84-2 V900773-250G 168.48CNY Detail
Aldrich (P14831)  Phenothiazine  ≥98% 92-84-2 P14831-1KG 936.00CNY Detail
Aldrich (P14831)  Phenothiazine  ≥98% 92-84-2 P14831-500G 552.24CNY Detail
Aldrich (P14831)  Phenothiazine  ≥98% 92-84-2 P14831-25G 193.05CNY Detail
Sigma-Aldrich (88580)  Phenothiazine  purum, ≥98.0% (GC) 92-84-2 88580-1KG 936.00CNY Detail
Sigma-Aldrich (88580)  Phenothiazine  purum, ≥98.0% (GC) 92-84-2 88580-250G 547.56CNY Detail
Sigma-Aldrich (88580)  Phenothiazine  purum, ≥98.0% (GC) 92-84-2 88580-50G 296.01CNY Detail
Sigma-Aldrich (46624)  Phenothiazine  VETRANAL, analytical standard 92-84-2 46624-250MG 360.36CNY Detail
Alfa Aesar (A12517)  Phenothiazine, 98+%    92-84-2 5000g 3351.0CNY Detail
Alfa Aesar (A12517)  Phenothiazine, 98+%    92-84-2 500g 389.0CNY Detail
Alfa Aesar (A12517)  Phenothiazine, 98+%    92-84-2 250g 204.0CNY Detail

92-84-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 10H-phenothiazine

1.2 Other means of identification

Product number -
Other names Thiodiphenylamine

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Intermediates,Process regulators,Processing aids, not otherwise listed
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:92-84-2 SDS

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