4-Hydroxy-3-phenylbutan-2-one

Base Information

• Chemical Name: 4-Hydroxy-3-phenylbutan-2-one
• CAS No.: 62559-37-9
• Molecular Formula: C10H12O2
• Molecular Weight: 164.204
• Hs Code.: 2914400090
• DSSTox Substance ID: DTXSID80491250
• Mol file: 62559-37-9.mol

Synonyms:4-HYDROXY-3-PHENYLBUTAN-2-ONE;62559-37-9;hydroxymethylphenylpropanone;SCHEMBL265795;DTXSID80491250;LXZMKGWDPDBHSO-UHFFFAOYSA-N;SB84642

Chemical Property of 4-Hydroxy-3-phenylbutan-2-one

Chemical Property:

• PSA: 37.30000
• LogP: 1.35150
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 164.083729621
• Heavy Atom Count: 12
• Complexity: 148

Purity/Quality:

97% ^*data from raw suppliers

4-Hydroxy-3-phenylbutan-2-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C(CO)C1=CC=CC=C1

Technology Process of 4-Hydroxy-3-phenylbutan-2-one

There total 4 articles about 4-Hydroxy-3-phenylbutan-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

3-Oxo-2-phenylbutanal (63726-68-1) → 1-Hydroxy-2-phenylbutan-3-one (62559-37-9)

Guidance literature:

With 1,3-dimethyl-2-phenyl-2,3-dihydro-1H-benzo[d]imidazole; In dichloromethane; at 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jo5025249

Reference yield: 48.0%

styrene oxide (96-09-3) + acetonitrile (75-05-8,26809-02-9) → styrene (100-42-5,25038-60-2,25247-68-1,28213-80-1,28325-75-9,79637-11-9,9003-53-6) + 2,3-diphenylbutane-1,4-diol (6583-62-6) + 1-Hydroxy-2-phenylbutan-3-one (62559-37-9)

Guidance literature:

styrene oxide; acetonitrile; With bis(cyclopentadienyl)titanium dichloride; zinc; In tetrahydrofuran; for 0.5h; Inert atmosphere;

With sodium dihydrogenphosphate; water; In tetrahydrofuran; for 0.333333h; Inert atmosphere;

DOI:10.1021/jo900479v

Reference yield: 40.0%

syn-/anti-1,2-Epoxy-3-phenylbutan-3-ol (101017-92-9) → 1-Hydroxy-2-phenylbutan-3-one (62559-37-9)

Guidance literature:

With tin(IV) chloride; In dichloromethane; at 0 ℃; for 1h;

DOI:10.1021/jo00074a019

upstream raw materials:

1,3,5-Trioxan

1-phenyl-2-trimethylsiloxy-1-propene

syn-/anti-1,2-Epoxy-3-phenylbutan-3-ol

styrene oxide

Downstream raw materials:

3-methyl-2-phenylbut-3-en-1-ol