(5-Chloro-2-methoxyphenyl)acetic acid

Base Information

• Chemical Name: (5-Chloro-2-methoxyphenyl)acetic acid
• CAS No.: 7569-62-2
• Molecular Formula: C9H8ClO3-
• Molecular Weight: 200.622
• Hs Code.: 2918990090
• European Community (EC) Number: 819-958-3
• DSSTox Substance ID: DTXSID50363632
• Wikidata: Q82147360
• Mol file: 7569-62-2.mol

Synonyms:(5-chloro-2-methoxyphenyl)acetic acid;7569-62-2;2-(5-chloro-2-methoxyphenyl)acetic acid;(5-Chloro-2-methoxy-phenyl)-acetic acid;Benzeneacetic acid, 5-chloro-2-methoxy-;MFCD02664695;Acetic acid, (5-chloro-2-methoxyphenyl)-;(5-CHLORO-2-METHOXYPHENYL)ACETICACID;SCHEMBL3870178;DTXSID50363632;HMS1741P20;5-chloro-2-methoxyphenylacetic acid;BBL020346;STK661760;5-Chloro-2-methoxy phenylacetic acid;AKOS000112343;SB38607;(5-chloro-2-methoxyphenyl)-Acetic acid;AC-23607;AS-10626;SY014174;[5-chloro-2-(methyloxy)phenyl]acetic acid;BB 0248981;CS-0012618;FT-0764032;EN300-14759;(5-chloro-2-methoxyphenyl)acetic acid, AldrichCPR;A865635;5-Chloro-2-methoxyphenylacetic acid - NEW PRODUCT;Z104346730

Chemical Property of (5-Chloro-2-methoxyphenyl)acetic acid

Chemical Property:

• Vapor Pressure: 0.000107mmHg at 25°C
• Boiling Point: 323.5°Cat760mmHg
• Flash Point: 149.4°C
• PSA: 46.53000
• Density: 1.312g/cm³
• LogP: 1.97570
• XLogP3: 2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 200.0240218
• Heavy Atom Count: 13
• Complexity: 184

Purity/Quality:

97% ^*data from raw suppliers

(5-Chloro-2-methoxyphenyl)aceticacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)Cl)CC(=O)O

Technology Process of (5-Chloro-2-methoxyphenyl)acetic acid

There total 8 articles about (5-Chloro-2-methoxyphenyl)acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-methoxyphenylacetic acid (93-25-4) → (5-chloro-2-methoxy-phenyl)-acetic acid (7569-62-2)

Guidance literature:

With sulfuryl dichloride; In tetrahydrofuran;

Reference yield: 70.0%

(5-chloro-2-methoxy-phenyl)-acetonitrile (7048-38-6) → (5-chloro-2-methoxy-phenyl)-acetic acid (7569-62-2)

Guidance literature:

With sulfuric acid; for 2h; Heating;

DOI:10.1002/bscb.19800890607

Reference yield:

2-(5-chloro-2-methoxy-phenyl)-1-morpholin-4-yl-ethanethione (917107-30-3) → (5-chloro-2-methoxy-phenyl)-acetic acid (7569-62-2)

Guidance literature:

2-(5-chloro-2-methoxy-phenyl)-1-morpholin-4-yl-ethanethione; With potassium hydroxide; ethanol; water; for 18h; Heating / reflux;

With hydrogenchloride; In water; at 0 ℃; for 0.25h;

upstream raw materials:

(5-chloro-2-methoxy-phenyl)-acetonitrile

2-methoxy-5-chloroacetophenone

4-chloromethoxybenzene

4-chloro-2-chloromethyl-1-methoxy-benzene

Downstream raw materials:

5-chloro-2-hydroxyphenylacetic acid

(5-chloro-2-methoxyphenyl)acetyl chloride

(2-Methoxy-5-chlor-phenyl)-aethanol

ethyl (5-chloro-2-hydroxyphenyl)acetate