2-(5-chloro-2-methoxy-phenyl)-1-morpholin-4-yl-ethanethione

Base Information

• Chemical Name: 2-(5-chloro-2-methoxy-phenyl)-1-morpholin-4-yl-ethanethione
• CAS No.: 917107-30-3
• Molecular Formula: C₁₃H₁₆ClNO₂S
• Molecular Weight: 285.795
• Mol file: 917107-30-3.mol

Synonyms:2-(5-chloro-2-methoxy-phenyl)-1-morpholin-4-yl-ethanethione

Chemical Property of 2-(5-chloro-2-methoxy-phenyl)-1-morpholin-4-yl-ethanethione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(5-chloro-2-methoxy-phenyl)-1-morpholin-4-yl-ethanethione

There total 1 articles about 2-(5-chloro-2-methoxy-phenyl)-1-morpholin-4-yl-ethanethione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

morpholine (110-91-8,99108-56-2) + 2-methoxy-5-chloroacetophenone (6342-64-9) → 2-(5-chloro-2-methoxy-phenyl)-1-morpholin-4-yl-ethanethione (917107-30-3)

Guidance literature:

With sulfur; at 20 ℃; for 8h; Heating / reflux;

Reference yield:

2-(5-chloro-2-methoxy-phenyl)-1-morpholin-4-yl-ethanethione (917107-30-3) → (5-chloro-2-methoxy-phenyl)-acetic acid (7569-62-2)

Guidance literature:

2-(5-chloro-2-methoxy-phenyl)-1-morpholin-4-yl-ethanethione; With potassium hydroxide; ethanol; water; for 18h; Heating / reflux;

With hydrogenchloride; In water; at 0 ℃; for 0.25h;

Reference yield:

2-(5-chloro-2-methoxy-phenyl)-1-morpholin-4-yl-ethanethione (917107-30-3) → 2-(2-(2-amino-2-oxoethyl)-4-chlorophenoxy)-N-((3-endo)-8-(4-chlorobenzyl)-8-azabicyclo[3.2.1]octan-3-yl)acetamide

Guidance literature:

Multi-step reaction with 5 steps

1.1: potassium hydroxide; ethanol; water / 18 h / Heating / reflux

1.2: 0.25 h / 0 °C

2.1: thionyl chloride / 2 h / 90 °C

3.1: ammonia / tetrahydrofuran / 20 °C

4.1: boron tribromide / dichloromethane / -10 - 20 °C

4.2: 0.17 h / 0 °C

5.1: potassium carbonate / N,N-dimethyl-formamide / 72 h / 50 °C

With potassium hydroxide; thionyl chloride; ethanol; ammonia; water; boron tribromide; potassium carbonate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

upstream raw materials:

morpholine

2-methoxy-5-chloroacetophenone

Downstream raw materials:

(5-chloro-2-methoxy-phenyl)-acetic acid

2-[5-chloro-2-(methyloxy)phenyl]acetamide

2-(5-chloro-2-hydroxyphenyl)-N-methylacetamide

(5-chloro-2-methoxyphenyl)acetyl chloride