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Technology Process of 4-pregnene-20,21-diol-3,11-dione

4-pregnene-20,21-diol-3,11-dione

Base Information
  • Chemical Name:4-pregnene-20,21-diol-3,11-dione
  • CAS No.:116-56-3
  • Molecular Formula:C21H30O4
  • Molecular Weight:346.467
  • Hs Code.:
  • Mol file:116-56-3.mol
4-pregnene-20,21-diol-3,11-dione

Synonyms:11-Dehydro-20-dihydrocorticosterone;20,21-Dihydroxy-4-pregnene-3,11-dione; 4-Pregnene-20,21-diol-3,11-dione;Reichstein's substance T

Suppliers and Price of 4-pregnene-20,21-diol-3,11-dione
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
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Total 7 raw suppliers
Chemical Property of 4-pregnene-20,21-diol-3,11-dione
Chemical Property:
  • PSA：74.60000 
  • LogP:2.66670 
Purity/Quality:

98%,99%, *data from raw suppliers

Safty Information:
  • Pictogram(s):  
  • Hazard Codes: 
MSDS Files:

SDS file from LookChem

Useful:
Technology Process of 4-pregnene-20,21-diol-3,11-dione

There total 2 articles about 4-pregnene-20,21-diol-3,11-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

11-dehydrocorticosterone
72-23-1

11-dehydrocorticosterone

11-dehydro-20-dihydrocorticosterone
116-56-3

11-dehydro-20-dihydrocorticosterone

Guidance literature:
With 20β-hydroxysteroid dehydrogenase; at 25 ℃; Rate constant; pH 6.4;
DOI:10.1248/cpb.28.730

Reference yield:

20β-21-Dihydroxypregn-4-en-3,11-dion
116-56-3,600-69-1,600-70-4

20β-21-Dihydroxypregn-4-en-3,11-dion

Guidance literature:
11b und CH3COOH;
DOI:10.1021/jo00973a034
upstream raw materials:

11-dehydrocorticosterone

Refernces

Generation of stable synthetic equivalents of unstable α-alkoxyacetaldehydes: An improved preparation of dirithromycin

10.1055/s-1993-26006

The research focuses on the development of a novel method for the in situ preparation of stable synthetic equivalents of unstable α-alkoxyacetaldehydes, with the specific application of improving the preparation of Dirithromycin (LY237216). The study addresses the challenges associated with the production and isolation of unstable α-alkoxyaldehydes, such as 2-methoxyethoxyacetaldehyde, which are prone to polymerization and decomposition. The researchers successfully synthesized the hemiacetal of 2-methoxyethoxyacetaldehyde by hydrolyzing its acetal precursor in aqueous acetonitrile solutions under mild conditions using p-toluenesulfonic acid as a catalyst. This hemiacetal served as a stable aldehyde equivalent, facilitating the efficient synthesis of Dirithromycin through its reaction with (9S)-erythromycylamine.

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