Synthesis p. 1089 - 1091 (1993)
Update date:2022-09-26
Topics:
McGill
Described is the in situ preparation of the hemiacetals of α-alkoxyacetaldehydes. The hemiacetals are generated by hydrolysis of an acetal precursor in aqueous acetonitrile solutions. These hemiacetals serve as stable aldehyde equivalents, thus circumventing the production and isolation of unstable α-alkoxyaldehydes. The hemiacetal of 2-methoxyethoxyacetaldehyde is utilized in an effective and efficient preparation of Dirithromycin (LY237216).
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Doi:10.1016/S0960-894X(00)00348-6
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(2001)Doi:10.1016/j.apcata.2012.12.021
(2013)Doi:10.1039/b002335n
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