5-[(4-methylphenyl)sulfonyl]-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline

Base Information

• Chemical Name: 5-[(4-methylphenyl)sulfonyl]-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline
• CAS No.: 10440-82-1
• Molecular Formula: C17H15 N3 O2 S
• Molecular Weight: 325.391
• Mol file: 10440-82-1.mol

Synonyms:2H-Pyrazolo[4,3-c]quinoline, 4,5-dihydro-5-(p-tolylsulfonyl)-(7CI,8CI)

Chemical Property of 5-[(4-methylphenyl)sulfonyl]-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline

Chemical Property:

• Vapor Pressure: 4.33E-14mmHg at 25°C
• Boiling Point: 594.2°Cat760mmHg
• Flash Point: 313.2°C
• Density: 1.401g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-[(4-methylphenyl)sulfonyl]-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline

There total 8 articles about 5-[(4-methylphenyl)sulfonyl]-4,5-dihydro-1H-pyrazolo[4,3-c]quinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-[1-Hydroxy-meth-(E)-ylidene]-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-quinolin-4-one (19596-46-4) → 5-tosyl-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (10440-82-1)

Guidance literature:

With hydrazine hydrate; acetic acid; In ethanol; Heating;

Reference yield:

C24H23N3O4S2 → 5-tosyl-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (10440-82-1)

Guidance literature:

With caesium carbonate; In 1,4-dioxane; at 100 ℃; for 1h; Inert atmosphere;

DOI:10.1055/s-0036-1591737

Reference yield:

N-(2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide (1224713-12-5) → 5-tosyl-4,5-dihydro-2H-pyrazolo[4,3-c]quinoline (10440-82-1)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 2 h / 20 °C / Inert atmosphere

2: caesium carbonate / 1,4-dioxane / 1 h / 100 °C / Inert atmosphere

With caesium carbonate; In 1,4-dioxane; acetonitrile;

DOI:10.1055/s-0036-1591737

upstream raw materials:

3-[1-Hydroxy-meth-(E)-ylidene]-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-quinolin-4-one

1-tosyl-2,3-dihydroquinolin-4(1H)-one

N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide

N-(2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide