N-(2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

Base Information

• Chemical Name: N-(2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide
• CAS No.: 1224713-12-5
• Molecular Formula: C₁₇H₁₅NO₃S
• Molecular Weight: 313.377
• Mol file: 1224713-12-5.mol

Synonyms:N-(2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

Chemical Property of N-(2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

There total 6 articles about N-(2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide (6590-65-4) + propargyl bromide (106-96-7) → N-(2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide (1224713-12-5)

Guidance literature:

With potassium carbonate; In acetone; for 4h; Reflux;

DOI:10.1016/j.tet.2013.04.069

Reference yield:

2-nitro-benzaldehyde (552-89-6) → N-(2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide (1224713-12-5)

Guidance literature:

Multi-step reaction with 3 steps

1: iron; hydrogenchloride / ethanol; water / 5 h / Inert atmosphere; Reflux; Schlenk technique

2: pyridine / dichloromethane / Inert atmosphere; Schlenk technique

3: potassium carbonate / N,N-dimethyl-formamide / Inert atmosphere; Schlenk technique

With pyridine; hydrogenchloride; iron; potassium carbonate; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1039/c4cc08339c

Reference yield:

2-Aminobenzyl alcohol (5344-90-1) → N-(2-formylphenyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide (1224713-12-5)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / dichloromethane / 3 h / 25 °C / Inert atmosphere

2: pyridinium chlorochromate / dichloromethane / 1.5 h / 25 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 6 h / 80 °C / Inert atmosphere

With pyridine; potassium carbonate; pyridinium chlorochromate; In dichloromethane; acetonitrile;

DOI:10.1021/acs.orglett.9b01295

upstream raw materials:

N-(2-Formyl-phenyl)-4-methyl-benzenesulfonamide

propargyl bromide

2-nitro-benzaldehyde

p-toluenesulfonyl chloride