Urea, 1-(4,7-dimethoxy-6-(2-(cyclohexylamino)ethoxy)-5-benzofuranyl)-3-methyl-

Base Information

Chemical Name:Urea, 1-(4,7-dimethoxy-6-(2-(cyclohexylamino)ethoxy)-5-benzofuranyl)-3-methyl-
CAS No.:66203-08-5
Molecular Formula:C₂₀H₂₉N₃O₅
Molecular Weight:391.467
Hs Code.:
DSSTox Substance ID:DTXSID60216387
Nikkaji Number:J87.658E
Wikidata:Q83092610
ChEMBL ID:CHEMBL297078

Synonyms:BRN 5161694;Urea, 1-(4,7-dimethoxy-6-(2-(cyclohexylamino)ethoxy)-5-benzofuranyl)-3-methyl-;66203-08-5;N-(4,7-Dimethoxy-6-(2-(cyclohexylamino)ethoxy)-5-benzofuranyl)-N'-methylurea;CHEMBL297078;DTXSID60216387;LS-159884;1-[4,7-Dimethoxy-6-[2-(cyclohexylamino)ethoxy]benzofuran-5-yl]-3-methylurea

Suppliers and Price of Urea, 1-(4,7-dimethoxy-6-(2-(cyclohexylamino)ethoxy)-5-benzofuranyl)-3-methyl-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemical Property of Urea, 1-(4,7-dimethoxy-6-(2-(cyclohexylamino)ethoxy)-5-benzofuranyl)-3-methyl-

Chemical Property:

Vapor Pressure:9.48E-12mmHg at 25°C
Boiling Point:540.5°Cat760mmHg
Flash Point:280.7°C
Density:1.22g/cm³
XLogP3:2.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:391.21072103
Heavy Atom Count:28
Complexity:489

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CNC(=O)NC1=C(C2=C(C(=C1OCCNC3CCCCC3)OC)OC=C2)OC

Technology Process of Urea, 1-(4,7-dimethoxy-6-(2-(cyclohexylamino)ethoxy)-5-benzofuranyl)-3-methyl-

There total 6 articles about Urea, 1-(4,7-dimethoxy-6-(2-(cyclohexylamino)ethoxy)-5-benzofuranyl)-3-methyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

: 108-91-8,157973-60-9
cyclohexylamine

: 66203-90-5
N-<6-(2-chloroethoxy)-4,4-dimethoxy-5-benzofuranyl>-N'-methylurea

: 66203-08-5
1-[6-(2-Cyclohexylamino-ethoxy)-4,7-dimethoxy-benzofuran-5-yl]-3-methyl-urea

Guidance literature:: With potassium carbonate; sodium iodide; In acetonitrile; for 15h; Heating;
DOI:10.1021/jm00134a007

Reference yield:

: 484-51-5
5-acetyl-6-hydroxy-4,7-dimethoxybenzofuran

: 66203-08-5
1-[6-(2-Cyclohexylamino-ethoxy)-4,7-dimethoxy-benzofuran-5-yl]-3-methyl-urea

Guidance literature:: Multi-step reaction with 6 steps

1: 82 percent / hydroxylamine hydrochloride, conc. NaOH / ethanol; H₂O / 6 h / Heating

2: 75 percent / aq. AcOH, HCl(g) / 0.5 h / 90 °C

3: 90 percent / HCl / ethanol / 20 h / Heating

4: 89 percent / CHCl₃ / 2 h / Ambient temperature

5: 62 percent / K₂CO₃ / acetonitrile / 4.5 h / Heating

6: 20 percent / NaI, K₂CO₃ / acetonitrile / 15 h / Heating

With hydrogenchloride; sodium hydroxide; hydroxylamine hydrochloride; potassium carbonate; acetic acid; sodium iodide; In ethanol; chloroform; water; acetonitrile;
DOI:10.1021/jm00134a007

Reference yield:

: 52631-79-5
N-(4,7-dimethoxy-6-hydroxy-5-benzofuranyl)acetamide

: 66203-08-5
1-[6-(2-Cyclohexylamino-ethoxy)-4,7-dimethoxy-benzofuran-5-yl]-3-methyl-urea

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / HCl / ethanol / 20 h / Heating

2: 89 percent / CHCl₃ / 2 h / Ambient temperature

3: 62 percent / K₂CO₃ / acetonitrile / 4.5 h / Heating

4: 20 percent / NaI, K₂CO₃ / acetonitrile / 15 h / Heating

With hydrogenchloride; potassium carbonate; sodium iodide; In ethanol; chloroform; acetonitrile;
DOI:10.1021/jm00134a007