2-chloro-N-(2-methoxyphenyl)pyridine-3-carboxamide

Base Information

• Chemical Name: 2-chloro-N-(2-methoxyphenyl)pyridine-3-carboxamide
• CAS No.: 62636-41-3
• Molecular Formula: C13H11ClN2O2
• Molecular Weight: 262.696
• DSSTox Substance ID: DTXSID10355497
• Wikidata: Q82134440

Synonyms:62636-41-3;2-chloro-N-(2-methoxyphenyl)pyridine-3-carboxamide;Oprea1_089466;Oprea1_189579;3-Pyridinecarboxamide, 2-chloro-N-(2-methoxyphenyl)-;SCHEMBL14880230;DTXSID10355497;AKOS000153299;EN300-200878;SR-01000390510;SR-01000390510-1;Z27797446

Chemical Property of 2-chloro-N-(2-methoxyphenyl)pyridine-3-carboxamide

Chemical Property:

• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 262.0509053
• Heavy Atom Count: 18
• Complexity: 288

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1NC(=O)C2=C(N=CC=C2)Cl

Technology Process of 2-chloro-N-(2-methoxyphenyl)pyridine-3-carboxamide

There total 1 articles about 2-chloro-N-(2-methoxyphenyl)pyridine-3-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-chloronicotinic acid (2942-59-8) + 2-methoxy-phenylamine (90-04-0) → 2-chloro-N-(2-methoxyphenyl)nicotinamide (62636-41-3)

Guidance literature:

2-chloronicotinic acid; With thionyl chloride; In N,N-dimethyl-formamide; benzene; at 80 ℃; for 2h;

2-methoxy-phenylamine; With triethylamine; In N,N-dimethyl-formamide; benzene; at 80 ℃; for 5h;

DOI:10.1021/ml300037k

Reference yield: 92.0%

2-chloro-N-(2-methoxyphenyl)nicotinamide (62636-41-3) + para-nitrobenzenethiol (1849-36-1) → N-(2-methoxyphenyl)-2-((4-nitrophenyl)thio)nicotinamide (1379464-91-1)

Guidance literature:

In N,N-dimethyl-formamide; at 110 ℃; for 6h;

DOI:10.1021/ml300037k

Reference yield:

2-chloro-N-(2-methoxyphenyl)nicotinamide (62636-41-3) + para-nitrobenzenethiol (1849-36-1) → N-(2-methoxyphenyl)-2-((4-nitrophenyl)thio)nicotinamide (1379464-91-1) + 2-methoxy-N-(4-nitrophenyl)aniline (729-04-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 5h;

DOI:10.1021/ml300037k

upstream raw materials:

2-chloronicotinic acid

2-methoxy-phenylamine

Downstream raw materials:

N-(2-methoxyphenyl)-2-((4-nitrophenyl)thio)nicotinamide

2-methoxy-N-(4-nitrophenyl)aniline

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