5-Hydroxy-2,3-dimethoxybenzaldehyde

Base Information

• Chemical Name: 5-Hydroxy-2,3-dimethoxybenzaldehyde
• CAS No.: 62648-55-9
• Molecular Formula: C9H10O4
• Molecular Weight: 182.176
• DSSTox Substance ID: DTXSID40576991
• Wikidata: Q82466893
• Mol file: 62648-55-9.mol

Synonyms:5-hydroxy-2,3-dimethoxybenzaldehyde;62648-55-9;DTXSID40576991

Chemical Property of 5-Hydroxy-2,3-dimethoxybenzaldehyde

Chemical Property:

• PSA: 55.76000
• LogP: 1.22190
• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 182.05790880
• Heavy Atom Count: 13
• Complexity: 171

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=CC(=C1OC)C=O)O

Technology Process of 5-Hydroxy-2,3-dimethoxybenzaldehyde

There total 4 articles about 5-Hydroxy-2,3-dimethoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,3-dimethoxy-5-nitrobenzaldehyde (6324-49-8) → 5-hydroxy-2,3-dimethoxybenzaldehyde (62648-55-9)

Guidance literature:

With sodium hydrogensulfite; iron(II) sulfate; calcium carbonate; Reagens 4:Wasser;Behandeln der filtrierten Reaktionsloesung mit wss.HCl und mit wss.NaNO₂ bei 3grad und Erwaermen der erhaltenen Diazoniumsalz-Loesung;

DOI:10.1021/ja01359a033

Reference yield:

1-bromo-5-hydroxy-2,3-dimethoxybenzene (93092-14-9) → 5-hydroxy-2,3-dimethoxybenzaldehyde (62648-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: dimethylformamide

2: Raney-Ni, 70percent HCOOH / 4 h / Heating

With formic acid; nickel; In N,N-dimethyl-formamide;

Reference yield:

1-cyano-5-hydroxy-2,3-dimethoxybenzene (93092-15-0) → 5-hydroxy-2,3-dimethoxybenzaldehyde (62648-55-9)

Guidance literature:

With formic acid; nickel; for 4h; Heating;

upstream raw materials:

2,3-dimethoxy-5-nitrobenzaldehyde

1-cyano-5-hydroxy-2,3-dimethoxybenzene

1-bromo-5-hydroxy-2,3-dimethoxybenzene

Downstream raw materials:

1-(3-nitrophenyl)-4,5,6-trimethoxy-8-(benzyloxy)-3,4-dihydroisoquinoline

1-phenyl-4,5,6-trimethoxy-8-(benzyloxy)-3,4-dihydroisoquinoline

2-<2,3-dimethoxy-5-(benzyloxy)phenyl>-2-methoxyethylamine

8-Benzyloxy-4,5,6-trimethoxy-1-(3-nitro-phenyl)-3,4-dihydro-isoquinoline; hydrochloride