6324-49-8

Usage

Uses

Used in Organic Synthesis:
2,3-dimethoxy-5-nitro-benzaldehyde is used as a reagent in organic synthesis for its ability to participate in a range of chemical reactions, facilitating the creation of diverse organic compounds.
Used in Perfumery:
In the fragrance industry, 2,3-dimethoxy-5-nitro-benzaldehyde is used as a fixative or scent component for its strong aromatic scent, enhancing the longevity and complexity of perfumes and fragrances.
Used in Pharmaceutical Industry:
2,3-dimethoxy-5-nitro-benzaldehyde is utilized as an intermediate in the synthesis of various drugs, playing a crucial role in the development of new pharmaceuticals.
Used in Materials Science:
In the field of materials science, 2,3-dimethoxy-5-nitro-benzaldehyde is used as a precursor in the production of polymers and other advanced materials, contributing to the development of innovative materials with unique properties.
As a nitrobenzaldehyde derivative, 2,3-dimethoxy-5-nitro-benzaldehyde's properties and applications make it a valuable chemical compound in a variety of industrial sectors.

InChI:InChI=1/C9H9NO5/c1-14-8-4-7(10(12)13)3-6(5-11)9(8)15-2/h3-5H,1-2H3

Upstream product

• 86-51-1 2,3-dimethyoxybenzaldehyde 
• 67-66-3 chloroform 
• 17028-61-4 5-nitro-o-vanilline 
• 74-88-4 methyl iodide 
• 7697-37-2 nitric acid 
• 64-19-7 acetic acid 
• 24677-78-9 2,3-dihydroxybenzaldehyde 
• 70490-42-5 Propionic acid 2-{[1-(2-hydroxy-3-methoxy-5-nitro-phenyl)-meth-(Z)-ylidene]-amino}-ethyl ester 
• 72543-76-1 2,3-dimethoxy-5-nitro-benzaldehyde dimethylacetal 

Downstream Products

• 72543-76-1 2,3-dimethoxy-5-nitro-benzaldehyde dimethylacetal 
• 17028-61-4 5-nitro-o-vanilline 
• 62648-55-9 5-hydroxy-2,3-dimethoxybenzaldehyde 
• 72517-25-0 2,3-dimethoxy-5-nitrobenzoic acid 
• 5556-84-3 2,3,5-trimethoxy-benzaldehyde 
• 1617498-51-7 C₂₅H₃₂BF₂N₃O₂ 
• 1617498-42-6 2,6-diethyl-4,4-difluoro-8-(2,3-dimethoxy-5-nitrophenyl)-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene 
• 1617498-56-2 8-(5-azido-2,3-dimethoxyphenyl)-2,6-diethyl-4,4-difluoro-1,3,5,7-tetramethyl-4-bora-3a,4a-diaza-s-indacene 
• 1093798-57-2 C₁₀H₁₄N₂O₄ 
• 52924-54-6 2,3-dihydroxy-5-nitro-benzaldehyde 

Relevant academic research and scientific papers

3-INDOLYL FURANOIDS AS INHIBITORS OF MATRIX METALLOPROTEINASE-9 FOR PREVENTION OF GASTRIC ULCER AND OTHER INFLAMMATORY DISEASES

Disclosed are 3-indolyl furanoid compounds which are useful as potent anti-inflammatory agents and prevent gastric ulcer by inhibiting matrix metalloproteinase-9 (MMP-9) expression in gastric mucosal layer. For example, disclosed is a compound of formula 1, wherein: R1 to R6 is selected from H, OH, CH3, OCH3, Br, Cl, Ph or o-OHC6H4, OCH2—CH═CH2, or OCH2CH2CH3, and R1 to R6 is having at least one substituent with alkyl, aryl and heteroaryl groups other than H, wherein the carbon in alkyl, aryl and heteroaryl is in the range of C1 to C8. Various embodiments relate to representative compounds of Formula 1 and method of preparation thereof. Further embodiments relates to the use of representative compounds of Formula 1 in treating diseases associated with gastric ulcer and other inflammatory diseases. A noted feature of an embodiment is the IC50 value of 50 μM of one of the 3-indolyl furanoids.

HIV-1 integrase strand-transfer inhibitors: Design, synthesis and molecular modeling investigation

This study is focused on a new series of benzylindole derivatives with various substituents at the benzene-fused ring, suggested by our 3D pharmacophore model developed for HIV-1 integrase inhibitors (INIs). All synthesized compounds proved to be active in the nanomolar range (6-35 nM) on the strand-transfer step (ST). In particular, derivative 4-[1-(4-fluorobenzyl)- 5,7-dimethoxy-1H-indol-3-yl]-2-hydroxy-4-oxobut-2-enoic acid (8e), presenting the highest best-fit value on pharmacophore model, showed a potency comparable to that of clinical INSTIs GS 9137 (1) and MK-0518 (2). The binding mode of our molecules has been investigated using the recently published crystal structure of the complex of full-length integrase from the prototype foamy virus in complex with its cognate DNA (PFV-IN/DNA). The results highlighted the ability of derivative 8e to assume the same binding mode of MK-0518 and GS 9137.

Synthesis and adrenolytic activity of new propanolamines

The synthesis of (2R, S)-1-(6-methoxy-4-(methoxymethyl)-1H-indol-5-yloxy)- 3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2R, S)-1-(4-methoxy-6- (methoxymethyl)-1H-indol-5-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol is described. The compound

Synthesis and adrenolytic activity of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxy phenoxy)ethylamino)propan-2-ol analogs and its enantiomers. Part 2

The synthesis of (2RS)-1-(5-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and (2RS)-1-(7-methoxy-1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol and its enantiomers, analogs of 1-(1H-indol-4-yloxy)-3-(2-(2-methoxyphenoxy)ethylamino)propan-2-ol ((RS)-9) is described. Compounds were tested for electrographic, antiarrhythmic, hypotensive and spasmolytic activities as well as for α1-, α2- and β1-adrenoceptors binding affinities. The antagonist potency of the new compounds was compared with carvedilol and (RS)-9.

NEW DS DNA BINDING FLUORESCENT DYES

The present invention is directed to a fluorescent dye comprising a benzothiazolium moiety and a pyrimidinium moiety connected by a mono-methine bridge, characterized in that (i) the 2-position of the pyrimidine carries a substituent which starts with a C

Antimicrobial indolequinones from the mid-intestinal gland of the muricid gastropod Drupella fragum

Three new indolequinones, 6-methoxyindole-4,7-quinone (1), 5- methoxyindole-4,7-quinone (2) and 5-methylindole-4,7-quinone (3) were isolated from the mid-intestinal gland of the muricid gastropod Drupella fragum. The structures of 1 and 2 were established