Technology Process of 5-(carboxymethoxy)-6,7-dichloro-2-propyl-1H-1-benzothiophene-1,1-diolate
There total 10 articles about 5-(carboxymethoxy)-6,7-dichloro-2-propyl-1H-1-benzothiophene-1,1-diolate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
3-chloro-benzenecarboperoxoic acid;
In
chloroform;
Ambient temperature;
DOI:10.1021/jm00395a020
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 85 percent / NaH / dimethylformamide / 0.5 h
2: SOCl2 / CH2Cl2 / 1 h / Heating
3: AlCl3 / CH2Cl2 / 1 h / Ambient temperature
4: NaBH4 / ethanol
5: 74 percent / BF3*OEt2 / acetic acid / 0.08 h / 120 °C
6: 60 percent / pyridine hydrochloride / 1 h / 180 °C
7: 76 percent / K2CO3 / dimethylformamide / 16 h / 70 - 80 °C
8: 95 percent / 85percent KOH / ethanol; H2O / 1 h / Heating
9: 61 percent / 85percent m-chloroperoxybenzoic acid / CHCl3 / Ambient temperature
With
potassium hydroxide; sodium tetrahydroborate; aluminium trichloride; thionyl chloride; boron trifluoride diethyl etherate; pyridine hydrochloride; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid;
In
ethanol; dichloromethane; chloroform; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00395a020
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 85 percent / NaH / dimethylformamide / 0.5 h
2: SOCl2 / CH2Cl2 / 1 h / Heating
3: AlCl3 / CH2Cl2 / 1 h / Ambient temperature
4: NaBH4 / ethanol
5: 74 percent / BF3*OEt2 / acetic acid / 0.08 h / 120 °C
6: 60 percent / pyridine hydrochloride / 1 h / 180 °C
7: 76 percent / K2CO3 / dimethylformamide / 16 h / 70 - 80 °C
8: 95 percent / 85percent KOH / ethanol; H2O / 1 h / Heating
9: 61 percent / 85percent m-chloroperoxybenzoic acid / CHCl3 / Ambient temperature
With
potassium hydroxide; sodium tetrahydroborate; aluminium trichloride; thionyl chloride; boron trifluoride diethyl etherate; pyridine hydrochloride; sodium hydride; potassium carbonate; 3-chloro-benzenecarboperoxoic acid;
In
ethanol; dichloromethane; chloroform; water; acetic acid; N,N-dimethyl-formamide;
DOI:10.1021/jm00395a020
![[(6,7-dichloro-2-n-propylbenzo[b]thien-5-yl)oxy]acetic acid](/Databaselist/images/loading.webp)
